Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Food & Water Gut & Microbiome Human Health Effects Marine & Wildlife Nanoplastics Policy & Risk Sign in to save

Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment

ACS ES&T Water 2023 14 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Haodong Cheng, Haodong Cheng, Xiang‐Rong Xu, Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Haodong Cheng, Jiazhen Wang, Elvis Genbo Xu Xiang‐Rong Xu, Haodong Cheng, Yuanyuan Tang, Xiang‐Rong Xu, Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Haodong Cheng, Haodong Cheng, Haodong Cheng, Haodong Cheng, Wenhui Qiu, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Haodong Cheng, Xiang‐Rong Xu, Haodong Cheng, Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Xiang‐Rong Xu, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Wenhui Qiu, Yuanyuan Tang, Haodong Cheng, Haodong Cheng, Chunmiao Zheng, Haodong Cheng, Chunmiao Zheng, Yuanyuan Tang, Haodong Cheng, Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Jason T. Magnuson, Jason T. Magnuson, Tao Chen, Tao Chen, Tao Chen, Tao Chen, Xiang‐Rong Xu, Wenhui Qiu, Wenhui Qiu, Jason T. Magnuson, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Jason T. Magnuson, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Yuanyuan Tang, Yuanyuan Tang, Xiang‐Rong Xu, Xiang‐Rong Xu, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Elvis Genbo Xu Haodong Cheng, Xiang‐Rong Xu, Wenhui Qiu, Yuanyuan Tang, Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Haodong Cheng, Jason T. Magnuson, Yuanyuan Tang, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Xiang‐Rong Xu, Yuanyuan Tang, Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Xiang‐Rong Xu, Yuanyuan Tang, Xiang‐Rong Xu, Yuanyuan Tang, Elvis Genbo Xu Xiang‐Rong Xu, Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Elvis Genbo Xu Xiang‐Rong Xu, Chunmiao Zheng, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Wenhui Qiu, Chunmiao Zheng, Yuanyuan Tang, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Elvis Genbo Xu Xiang‐Rong Xu, Chunmiao Zheng, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Chunmiao Zheng, Yuanyuan Tang, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Xiang‐Rong Xu, Yuanyuan Tang, Xiang‐Rong Xu, Chunmiao Zheng, Yuanyuan Tang, Xiang‐Rong Xu, Elvis Genbo Xu Wenhui Qiu, Elvis Genbo Xu Yuanyuan Tang, Elvis Genbo Xu Xiang‐Rong Xu, Xiang‐Rong Xu, Elvis Genbo Xu

Summary

Researchers investigated how nanoplastics accumulate in zebrafish intestines through different exposure routes, including waterborne, foodborne, and combined pathways. They found that while foodborne exposure led to higher particle accumulation, both routes caused similar levels of intestinal inflammation and immune disruption. The study suggests that current risk assessments based on single-route exposure may underestimate the true danger of nanoplastic pollution in aquatic environments.

Polymers

Body Systems

Immune

Models

Zebrafish

The global impact of nanoplastics (NPs) as emerging pollutants on water environments remains uncertain. Previous studies have focused on the toxicity of NPs itself, often ignoring the important effects of exposure routes. Here, we evaluated the impact of different exposure routes (waterborne, foodborne, and coexposure) of 80 nm polystyrene NPs on intestinal accumulation and inflammatory response using zebrafish. Our results demonstrated that aqueous and dietary exposures led to both time- and dose-dependent bioaccumulation of NPs, damaged intestinal structure, and induced immune cells and genes in the intestine. While waterborne exposure caused lower NPs accumulation than foodborne exposure, both demonstrated similar immunotoxicity in the intestine. In addition, co-exposure can lead to a higher accumulation of NPs and toxicity in zebrafish, suggesting that the risk of environmental exposure may be underestimated, as current toxicity assessments have focused on single-route exposure scenarios. We further revealed that NPs activated downstream genes of the toll-like 4 receptor, suggesting that NPs can cause an inflammatory response. Our study is the first known to report that exposure to NPs via different routes induces an accumulation in the intestine and can cause similar intestinal disturbance effects, providing new insights for adequately assessing the potential risks of NPs.

Read via DOI

Share this paper

Post Share Share Pin Email