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Estrogenic activity of plastic nanoparticle mixtures under in vitro settings
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This study investigated the endocrine disrupting effects of polyethylene, polystyrene, and polypropylene nanoparticles individually and in mixtures under in vitro conditions. Results provided science-based evidence of estrogenic activity from all three nanoparticle types, emphasizing the importance of assessing aggregate exposure to nanoplastic mixtures rather than individual polymers.
This study provides science-based evidence on endocrine disrupting effects of polyethylene, polystyrene and polypropylene nanoparticles and their mixtures indicating the importance of hazard assessment of aggregate exposure to nanoplastics.
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Surface-driven endocrine activity of nanoplastics: polymer- and size-dependent estrogen and androgen receptors modulation without steroidogenesis perturbation
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Scientists tested tiny plastic particles from common plastics (like polyethylene and polypropylene, found in packaging and cosmetics) to see if they mess with hormone signals in human cells. They found that certain plastic types and sizes could mimic estrogen or block testosterone activity on their own—and surprisingly, mixtures of plastics sometimes caused hormone disruption even when the individual plastics alone didn't. This suggests that not all plastics affect our hormones the same way, and real-world exposure to plastic mixtures (as we'd actually encounter them) may pose risks that testing single plastics alone would miss
Nanoplastics increase in vitro oestrogenic activity of neurotherapeutic drugs
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Researchers found that polystyrene nanoplastics significantly enhance the estrogenic activity of neurotherapeutic drugs in vitro, suggesting that nanoplastic contamination of drinking water and food could increase hormonal exposures from pharmaceutical residues.
Endocrine Disrupting Activity of Mixtures Composed of Pharmaceuticals and Nanoplastics
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This study investigated the combined endocrine-disrupting activity of pharmaceutical compounds mixed with nanoplastics, examining how the mixture behaves differently from individual components. Nanoplastics can adsorb and concentrate endocrine-disrupting chemicals from the environment, potentially delivering combined hormonal effects to organisms that ingest them.
Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor
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This study found that both nanoplastic polystyrene particles and silver nanoparticles (AgNPs) activate estrogen signaling in breast cancer cells by binding to cytoplasmic estrogen receptors. The results suggest these two common nanomaterials are endocrine disruptors capable of mimicking estrogenic activity, with potential implications for hormone-driven diseases.
Single and joint exposure to nanoplastics and bisphenols: a comparative assessment of in vitro hazards
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This study compared the individual and combined toxicity of nanoplastics and bisphenol compounds in biological test systems, finding synergistic effects at certain exposure combinations. The results indicate that co-exposure to these two common plastic-associated contaminants may be more harmful than either alone.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.