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The Effect of Polyethylene Terephthalate Microplastics on the Growth of Mice
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Mice were fed diets containing 0, 300, or 600 ug PET microplastics for an experimental period to examine effects on body weight, feces weight, and feed consumption. Food contaminated with microplastics altered growth metrics compared to controls, raising concerns about dietary microplastic exposure effects on mammalian health.
Over the course of the previous decade, there has been a growing apprehension regarding the presence of MPs. This concern has arisen because of the detrimental effects of MPs pollution on the well-being of both animals and people. This study explores the potential implications of MPs contamination on mice. This study examined the impact of microplastics on mice by feeding four food experiment; P0 (pellet BR1), P1 (potato from Pujon Farm), P2 (potato mixed 300 µg PET) and P3 (potato mixed 600 µg PET). Body weight, feces weight, and left feed were observed in this study. Food contaminated with microplastics (MPs) has a negative effect on appetite, feces weight and body weight of mice. This process has an impact on reducing the weight of feces, appetite, body weight of mice and weight of mice. It is suspected that MPs in rat digestion increase concentrations of mice corticosterone metabolites and carcass fat, suggesting an adaptation of metabolism to this situation. Another impact is expected the decrease in microbial richness in the intestines of mice, causing a decrease in mice weight and body weight of mice. The high concentration of MPs entering the digestive tract can also reduce the rats’ appetite.
More Papers Like This
Potential Impact Microplastic Polyethylene Terephthalate on Mice
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Researchers studied how polyethylene terephthalate (PET) microplastics affect mice when ingested, tracking where the particles end up in the body. They found that microplastics accumulated in various organs and caused measurable biological effects. The study adds to growing evidence that common plastic types found in food packaging may pose health risks when consumed.
Toxicological Evaluations Following 28-Day Oral Gavage Exposure to Polyethylene Terephthalate Microplastic Particles in Mice
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Mice were fed PET microplastics daily for 28 days at different doses. No major health effects showed up in body weight, blood tests, or organ weights, but male mice had minor kidney changes and both sexes showed fewer gut goblet cells, without visible damage to the gut lining.
Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice
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Mice exposed to PET microplastics, the type commonly found in plastic bottles, developed intestinal inflammation, changes in gut bacteria, and signs of a weakened gut barrier. Even at relatively low doses, the microplastics increased liver stress markers and disrupted the protective mucus layer in the colon, suggesting that everyday PET plastic exposure could contribute to digestive health problems.
Impact of particulate microplastics generated from polyethylene terephthalate on gut pathology and immune microenvironments
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Researchers generated particulate microplastics from polyethylene terephthalate (PET) and investigated their impact on gut health using mouse models, histological examinations, and multi-omics analysis. The study found that while chronic low-dose PET microplastic exposure did not cause visible intestinal damage, it did alter the gut immune microenvironment and microbiota composition, suggesting subtle but measurable biological effects.
Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation
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Researchers administered polyethylene microplastics to mice by oral gavage for 90 days and observed significant effects including reduced body weight gain, increased neutrophil counts, and immune system changes. Microplastic-like material persisted in stomach tissue, and immune markers were altered in treated animals. A follow-up reproductive study found that microplastic exposure affected the number of live births, sex ratio of pups, and offspring immune cell populations, suggesting the need for further reproductive toxicity testing.
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