We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Testis–Gut‐Reproduction Axis: The Key to Reproductive Health
Summary
This review explores the connection between gastrointestinal health and male reproductive function, describing a testis-gut-reproduction axis. Researchers found that gut hormones and gut microbiota can either promote or inhibit testicular functions including sperm production and hormone regulation. The study suggests that maintaining gut health may be an important factor in supporting male fertility.
Reproductive health is an important issue for humanity. In the context of the increasing incidence rate of male infertility, it is essential to find the factors that affect male reproductive health. Gastrointestinal health is closely related to reproductive health. Gastrointestinal hormones (GIH) and gut microbiota (GM), as important material foundations for gastrointestinal function, can promote or inhibit testicular reproductive function, including spermatogenesis, sperm maturation, androgen synthesis, and even broader male diseases such as sexual function, prostate cancer, etc. On the contrary, the functional health of the testes is also of great significance for the stability of gastrointestinal function. This review mainly discusses the important regulatory effects of GIH and GM on male reproductive function.
Sign in to start a discussion.
More Papers Like This
Gut microbiota is involved in male reproductive function: a review
This review summarizes how gut bacteria influence male reproductive health, including sperm quality, testicular health, sex hormone levels, and sexual behavior. The findings suggest that an unhealthy gut microbiome may contribute to male infertility, while probiotic supplements could potentially improve reproductive function -- an important connection as microplastics are known to disrupt gut bacteria.
In Vitro Insights on a Gut–Testis Axis Model by a Nutraceutical Combination of Ceratonia siliqua, Ribonucleotides and Bifidobacterium longum
Scientists tested a combination of carob extract, beneficial bacteria, and ribonucleotides (building blocks of DNA/RNA) on lab-grown cells to see how gut health affects male fertility. The mixture improved intestinal barrier function and protected testicular cells from damage caused by harmful molecules called free radicals. While this is early lab research, it suggests that supporting gut health with specific nutrients might help protect male reproductive function from environmental stressors.
Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility
This review explores the growing understanding of microbial communities found in seminal fluid and their potential role in male fertility. Researchers found that certain bacterial populations are associated with healthy reproductive function, while imbalances in these communities may correlate with fertility challenges. The study highlights the seminal microbiome as an emerging area of research that could lead to new approaches for understanding and addressing reproductive health.
Research trend on the emerging role of the microbiome in idiopathic male infertility
A bibliometric analysis of global research on idiopathic male infertility over two decades found a clear transition from genetic and oxidative stress approaches toward microbiome-centered and multi-omics investigations, reflecting growing interest in the gut-reproductive axis.
The hidden threat: Unraveling the impact of microplastics on reproductive health
This review summarizes how microplastics disrupt the reproductive system in both males and females by interfering with hormone signaling, damaging the blood-testis barrier, impairing sperm production, and causing problems in the ovaries and uterus. The authors also note that microplastic exposure may affect offspring development, including their future reproductive capacity and metabolism.