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Polyethylene terephthalate nanoplastics promote gastric cancer progression by inhibiting the TNF-α/JAK1/STAT1 signaling pathway and shaping an immunosuppressive microenvironment
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Long‑term exposure of polyethylene nanoplastics promotes colorectal tumorigenesis
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Researchers exposed mice to polyethylene nanoplastics over 66 days and found significantly more colon tumors and heavier tumor burdens compared to controls, with nanoplastics alone triggering colorectal polyps, suggesting these particles promote tumor initiation by disrupting mitochondrial structure and amplifying chronic intestinal inflammation.
Polyethylene terephthalate nanoplastics promote gastric cancer progression by inhibiting the TNF-α/JAK1/STAT1 signaling pathway and shaping an immunosuppressive microenvironment
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Tiny plastic particles from PET plastic (commonly used in bottles and food packaging) may do more than just contaminate our bodies—new research in mice and lab-grown cells shows they can actually help stomach cancer grow faster and resist chemotherapy. These nanoplastics appear to weaken the immune system's ability to fight tumors and block a key cancer-suppressing pathway in the body. While this study was done in mice and cells rather than humans, it adds to growing evidence that chronic exposure to microplastics isn't just an environmental issue—it could be a real risk factor for cancer progression.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
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Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Impact of Micro-nanoplastics on Gut and Immune Function
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This review examined how micro- and nanoplastics disrupt gut microbiota and immune function across aquatic and terrestrial vertebrates, with implications for human health. Because the gut microbiome governs immune regulation and metabolic health, microplastic-induced dysbiosis represents a plausible mechanism by which plastic ingestion could drive systemic inflammation and disease beyond the GI tract.
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