We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Systemic investigation of di-isobutyl phthalate (DIBP) exposure in the risk of cardiovascular via influencing the gut microbiota arachidonic acid metabolism in obese mice model
AI summary Read the abstract
Researchers studied how di-isobutyl phthalate, a plasticizer chemical commonly found in food and water, affects cardiovascular health in both normal and obese mice. They found that the compound disrupted gut bacteria and altered fat metabolism pathways, with obese mice showing more severe effects including increased cardiovascular risk markers. The study suggests that exposure to this common plastic-related chemical may contribute to heart disease risk, particularly in people who are already overweight.
Phthalate esters (PE), a significant class of organic compounds used in industry, can contaminate humans and animals by entering water and food chains. Recent studies demonstrate the influence of PE on the development and progression of heart diseases, particularly in obese people. Di-isobutyl phthalate (DIBP) was administered orally to normal and diet-induced obese mice in this research to assess cardiovascular risk. The modifications in the microbial composition and metabolites were examined using RNA sequencing and mass spectrometry analysis. Based on the findings, lean group rodents were less susceptible to DIBP exposure than fat mice because of their cardiovascular systems. Histopathology examinations of mice fed a high-fat diet revealed lesions and plagues that suggested a cardiovascular risk. In the chronic DIBP microbial remodeling metagenomics Faecalibaculum rodentium was the predominant genera in obese mice. According to metabolomics data, arachidonic acid (AA) metabolism changes caused by DIBP were linked to unfavorable cardiovascular events. Our research offers new understandings of the cardiovascular damage caused by DIBP exposure in obese people and raises the possibility that arachidonic acid metabolism could be used as a regulator of the gut microbiota to avert related diseases.
More Papers Like This
The influence of microplastics on hypertension-associated cardiovascular injury via the modulation of gut microbiota
AI summary Read the abstract
Researchers found that people with high blood pressure had more microplastics in their stool samples than healthy individuals, and feeding microplastics to mice raised their blood pressure and caused heart damage. The harm was linked to changes in gut bacteria, and a high-fiber diet or antibiotics helped reduce the damage. This study suggests microplastic exposure may worsen heart and blood pressure problems by disrupting the gut microbiome.
Gut microbiota and metabolic health risks from chronic low-dose microplastic exposure with focus on Desulfovibrio spp.
AI summary Read the abstract
Researchers investigated the effects of long-term, low-dose polystyrene microplastic intake on gut bacteria and metabolism in mice. They found that even low doses significantly altered the gut microbiome, increasing bacteria linked to gastrointestinal inflammation and colorectal cancer risk, while also disrupting lipid and amino acid metabolism. The study suggests that routine microplastic exposure through food and water could quietly shift gut health in ways associated with chronic metabolic conditions.
Microplastic exposure and obesity-related metabolic dysfunction: A proposed gut microbiota-metabolite framework.
AI summary Read the abstract
This review paper summarizes existing research on how microplastics eaten with food might affect gut bacteria, gut lining health, and body fat in animal studies and lab cell experiments. It suggests microplastics could disrupt gut microbes and cause inflammation linked to obesity-related problems, but notes gaps in long-term testing and uncertainty about applying findings across species.
Phthalates released from microplastics inhibit microbial metabolic activity and induce different effects on intestinal luminal and mucosal microbiota
AI summary Read the abstract
Researchers used a simulated human gut model to show that intestinal microbiota accelerates the release of phthalate plasticizers from microplastics, and these released phthalates inhibit microbial metabolic activity and differentially affect luminal versus mucosal gut bacteria.
Probing the Cardiovascular Toxic Effects of Long-Term Exposure to Dibutyl Phthalate in Sprague-Dawley Rats Based on Oxidative Inflammation and Metabolic Pathways: Implications for the Heart and Blood Vessel
AI summary Read the abstract
This study investigates the effects of prolonged microplastic exposure on cardiovascular health, examining how particles accumulate in cardiac tissues and disrupt normal function. Researchers documented toxic responses including inflammation, oxidative stress, and structural changes in heart and vascular tissue. The findings raise concern about the long-term cardiovascular risks posed by chronic microplastic exposure in humans and animals.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.