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Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Summary
Researchers found that blocking the protein CRTC1 protected mice from severe lung damage caused by sepsis — a life-threatening immune overreaction to infection — by activating a protective signaling pathway called Akt that reduces inflammation and cell death. This suggests CRTC1 could be a promising drug target for treating sepsis-induced acute lung injury in clinical settings.
Our study demonstrates that CRTC1 contribute to the pathological processes of inflammation and apoptosis in sepsis-induced ALI, and provides mechanistic insights into the molecular function of CRTC1 in the lung. Targeting CRTC1 would be a promising strategy to treat sepsis-induced ALI in clinic.
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