Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
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Integrin A5B1-mediated endocytosis of polystyrene nanoplastics: Implications for human lung disease and therapeutic targets
The Science of The Total Environment2024
19 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Mingming Han,
Qichen Jiang,
Mingming Han,
Ji Liang,
Zihan Zhou,
Yi Juin Tay,
Ji Liang,
Chenxi Zhu,
Chenxi Zhu,
Chenxi Zhu,
Ji Liang,
Qichen Jiang,
Yi Juin Tay,
Mingming Han,
Mingming Han,
Anisah Lee Binti Abdullah,
Anisah Lee Binti Abdullah,
Anisah Lee Binti Abdullah,
K. Wang,
Anisah Lee Binti Abdullah,
Zihan Zhou,
Anisah Lee Binti Abdullah,
Anisah Lee Binti Abdullah,
Ji Liang,
Zihan Zhou,
Ji Liang,
Qichen Jiang,
Yi Juin Tay,
Qichen Jiang,
Qichen Jiang,
Anisah Lee Binti Abdullah,
Anisah Lee Binti Abdullah,
Yi Juin Tay,
Zihan Zhou,
Zihan Zhou,
Zihan Zhou,
Yunlong Zhao,
Anisah Lee Binti Abdullah,
Ji Liang,
Anisah Lee Binti Abdullah,
K. Wang,
K. Wang,
Qichen Jiang,
Qichen Jiang,
Aileen Tan Shau Hwai
Qin Si,
K. Wang,
Qichen Jiang,
Qichen Jiang,
Qin Si,
Chenxi Zhu,
Qin Si,
Qin Si,
Ji Liang,
Qichen Jiang,
Qichen Jiang,
Yunlong Zhao,
Qichen Jiang,
Chenxi Zhu,
Qichen Jiang,
Qichen Jiang,
Qichen Jiang,
Qin Si,
Chenxi Zhu,
Aileen Tan Shau Hwai
Qichen Jiang,
Yunlong Zhao,
Ji Liang,
Zihan Zhou,
Qichen Jiang,
Mingming Han,
Chenxi Zhu,
Mingming Han,
Anisah Lee Binti Abdullah,
Chenxi Zhu,
Yi Juin Tay,
Qichen Jiang,
Yi Juin Tay,
Mingming Han,
Mingming Han,
Yunlong Zhao,
Qichen Jiang,
Yunlong Zhao,
Qichen Jiang,
Yunlong Zhao,
Anisah Lee Binti Abdullah,
Aileen Tan Shau Hwai
Qichen Jiang,
Qichen Jiang,
Qichen Jiang,
Anisah Lee Binti Abdullah,
Nurzalina Abdul Karim Khan,
Yunlong Zhao,
Yunlong Zhao,
Zihan Zhou,
Yunlong Zhao,
Yunlong Zhao,
Yunlong Zhao,
Yunlong Zhao,
Chenxi Zhu,
Anisah Lee Binti Abdullah,
Qichen Jiang,
Jiayuan Liao,
Qichen Jiang,
Ji Liang,
Qichen Jiang,
Mingming Han,
Qin Si,
Ji Liang,
Qin Si,
Yi Juin Tay,
Qichen Jiang,
Qichen Jiang,
Anisah Lee Binti Abdullah,
Yunlong Zhao,
Yunlong Zhao,
Yunlong Zhao,
Yunlong Zhao,
Yunlong Zhao,
Yi Juin Tay,
Anisah Lee Binti Abdullah,
Qin Si,
Yunlong Zhao,
Anisah Lee Binti Abdullah,
Yunlong Zhao,
Qin Si,
Yunlong Zhao,
Qichen Jiang,
Anisah Lee Binti Abdullah,
Qin Si,
Qichen Jiang,
Qin Si,
Yunlong Zhao,
Qichen Jiang,
Yunlong Zhao,
Yunlong Zhao,
Aileen Tan Shau Hwai
Yunlong Zhao,
Aileen Tan Shau Hwai
Qichen Jiang,
Yiming Li,
Qichen Jiang,
Qichen Jiang,
Zihan Zhou,
Mingming Han,
Chunqi Jiang,
Qichen Jiang,
Jiayuan Liao,
Yi Juin Tay,
Yi Juin Tay,
Wei Qin,
Qichen Jiang,
Aileen Tan Shau Hwai
Summary
This study identified a specific protein, integrin alpha-5-beta-1, as a key gateway that allows polystyrene nanoplastics to enter human lung cells. Once inside, the nanoplastics triggered inflammation, oxidative stress, and cell damage that could contribute to respiratory disease and lung cancer risk. The discovery of this entry mechanism could provide a potential drug target for reducing the harmful effects of inhaled nanoplastics on lung health.
The extensive use of plastic products has exacerbated micro/nanoplastic (MPs/NPs) pollution in the atmosphere, increasing the incidence of respiratory diseases and lung cancer. This study investigates the uptake and cytotoxicity mechanisms of polystyrene (PS) NPs in human lung epithelial cells. Transcriptional analysis revealed significant changes in cell adhesion pathways following PS-NPs exposure. Integrin α5β1-mediated endocytosis was identified as a key promoter of PS-NPs entry into lung epithelial cells. Overexpression of integrin α5β1 enhanced PS-NPs internalization, exacerbating mitochondrial Ca2+ dysfunction and depolarization, which induced reactive oxygen species (ROS) production. Mitochondrial dysfunction triggered by PS-NPs led to oxidative damage, inflammation, DNA damage, and necrosis, contributing to lung diseases. This study elucidates the molecular mechanism by which integrin α5β1 facilitates PS-NPs internalization and enhances its cytotoxicity, offering new insights into potential therapeutic targets for microplastic-induced lung diseases.