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Uptake of Breathable Nano- and Micro-Sized Polystyrene Particles: Comparison of Virgin and Oxidised nPS/mPS in Human Alveolar Cells

Preprints.org 2023 6 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Giuseppa Visalli, A. Laganà, A. Laganà, A. Laganà, A. Laganà, Alessio Facciolà, Giuseppa Visalli, A. Laganà, Giuseppa Visalli, Consuelo Celesti, A. Laganà, Alessio Facciolà, Giuseppa Visalli, Giuseppa Visalli, Giuseppa Visalli, Giuseppa Visalli, Alessio Facciolà, Alessio Facciolà, Alessio Facciolà, Alessio Facciolà, Daniela Iannazzo, Alessio Facciolà, Angela Di Pietro Consuelo Celesti, Consuelo Celesti, Alessio Facciolà, Daniela Iannazzo, Alessio Facciolà, Daniela Iannazzo, Angela Di Pietro Giuseppa Visalli, A. Laganà, Angela Di Pietro Angela Di Pietro Consuelo Celesti, Angela Di Pietro Consuelo Celesti, Daniela Iannazzo, Angela Di Pietro Daniela Iannazzo, Angela Di Pietro

Summary

Researchers found that environmentally aged (oxidised) nano- and microplastics were rapidly taken up by human lung cells and caused significantly greater DNA damage, oxidative stress, and mitochondrial impairment compared to pristine particles, highlighting the heightened health risks of weathered airborne plastics.

Polymers

Body Systems

Respiratory

Airborne micro- and nanoplastics are widely spread and pose a risk to human health. The effects of virgin (v) and home oxidised (ox) nano- and micropolystyrene (nPS/mPS) (0.1 and 1 µm) were studied on the human alveolar cells (A549). Ox-nPS/mPS, simulating photoaging, allowed effects due to environmental wear to be assessed. Cellular uptake was quantified using FITC-functionalised nPS/mPS, while cytotoxicity, changes in the acidic compartment, ROS production, mitochondrial function and DNA damage were assessed to study the effects of internalised v- and ox-nPS/mPS. The uptake was dose-dependent and very fast, since, at the lowest dose, 20.8% and 21.8% of nPS and mPS, respectively, were internalised after 1 h. Compared to v-, significant ROS increases, DNA damage and mitochondrial impairment were observed after exposure to ox-nPS/mPS. The enhancement of effects due to environmental aging processes highlighted the true potential impact on human health of these airborne pollutants.

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