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Early-life polystyrene nanoplastics exposure impairs pathogen avoidance behavior associated with intestine-derived insulin-like neuropeptide (ins-11) and serotonin signaling in Caenorhabditis elegans
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Researchers found that early-life exposure to polystyrene nanoplastics at environmentally relevant concentrations significantly impaired the ability of the model organism C. elegans to avoid pathogenic bacteria. The nanoplastics disrupted an intestine-derived neuropeptide signaling pathway and serotonin signaling, both essential for pathogen avoidance behavior. The study suggests that early-life nanoplastic exposure could make organisms more vulnerable to harmful pathogens by interfering with protective behavioral responses.
Nanoplastics (NPs) contamination is an emerging global concern due to the widespread use of plastic products and their potentially negative health impact on ecosystems. Despite their ubiquity, the effects of early-life NPs exposure on host-pathogen interactions remain largely unknown. In this study, we show that early-life exposure to polystyrene NPs (PS-NPs, 100-nm) at predicted environmentally relevant concentrations (10 µg/L) significantly impairs food preference and reduces avoidance of the pathogenic bacterium Bacillus thuringiensis in Caenorhabditis elegans. Exposure to PS-NPs led to a decrease in avoidance from 40.3 % in controls to 30.6 % at 10 µg/L and further to 23.1 % and 17.4 % at 50 and 100 µg/L, respectively. Mechanistic insights reveal that PS-NPs downregulate intestine-derived insulin-like neuropeptide (ins-11) via the transcription factor HLH-30 and the p38 MAPK signaling pathways, both are essential for avoidance behavior. Notably, acute serotonin treatment restored the avoidance behavior, indicating a role of serotonin signaling in this process. Our study indicates that early-life exposure to PS-NPs (100-nm) adversely affects the avoidance behavior of C. elegans, making them more vulnerable to harmful pathogens, thereby affecting their health. These findings highlight significant ecological and health hazards by early-life PS-NPs exposure.
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Researchers found that exposure to polystyrene nanoparticles at low, environmentally realistic concentrations made a bacterial infection significantly more harmful to the roundworm C. elegans. The nanoparticles increased bacterial accumulation in the worms' bodies and weakened their innate immune responses. The study suggests that nanoplastic pollution in the environment could amplify the toxicity of common microbial pathogens.
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Researchers exposed Caenorhabditis elegans to nanopolystyrene and characterized changes in tyramine and glutamate neurotransmitter pathways, finding that nanoplastic exposure disrupted both signaling systems and that mutations in these pathways altered the worm's sensitivity to nanoplastic toxicity.
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