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Micro- and Nanoplastics in the Brain: A Scoping Review Protocol on Their Presence, Neurotoxic Effects, and Implications for Human Health
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This scoping review protocol outlines a systematic approach to mapping scientific evidence on the presence of micro- and nanoplastics in the brain, their neurotoxic effects, and potential implications for human health. The review will chart findings from both human studies and experimental models to identify key mechanisms, affected brain regions, and knowledge gaps in this emerging field.
This scoping review protocol aims to map the scientific evidence on the presence of micro- and nanoplastics in the brain, their neurotoxic effects, and potential implications for human health. Evidence from human studies and experimental models will be systematically charted following JBI methodology and PRISMA-ScR guidelines to identify key mechanisms, affected brain regions, and knowledge gaps.
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Micro- and Nanoplastics in the Brain: A Scoping Review Protocol on Their Presence, Neurotoxic Effects, and Implications for Human Health
AI summary Read the abstract
This scoping review protocol maps scientific evidence on the presence of micro- and nanoplastics in the brain, their neurotoxic effects, and implications for human health, drawing from both human studies and experimental models. The protocol follows JBI methodology to systematically chart available evidence.
Micro- and Nanoplastics in the Human Brain: Mechanistic Plausibility, Translational Challenges, and Links to Neurological Disease Trends.
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Researchers synthesized evidence that micro- and nanoplastics can accumulate in human brain tissue via multiple barrier-crossing routes and, once there, disrupt synaptic function, mitochondrial homeostasis, and neuroinflammatory pathways relevant to Alzheimer's, Parkinson's, stroke, and mood disorders — while emphasizing that longitudinal epidemiological evidence linking plastic exposure to neurological disease remains limited.
Microplastics and Human Neurotoxicity: An Umbrella Review and Theoretical Integration [SCIENTIFIC V5.0 - Q1 HIGH-IMPACT]
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This research analyzed legal frameworks and regulatory approaches for addressing microplastic pollution at national or international levels, identifying gaps and proposing improvements. The study highlights the need for more comprehensive and harmonized governance structures to effectively reduce plastic pollution.
Microplastics and Human Neurotoxicity: An Umbrella Review and Theoretical Integration [SCIENTIFIC V5.0 - Q1 HIGH-IMPACT]
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This study investigated microplastic identification in squid tissues, developing or applying analytical methods to detect and characterize ingested plastic particles. The findings provide data on microplastic uptake in commercially important cephalopod species, with implications for seafood safety and marine food web contamination.
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This research examined the fate of microplastics in sewage sludge ash following incineration, assessing whether thermal treatment destroys plastic particles or produces new chemical contaminants. The study evaluated the implications of sludge combustion for the environmental fate of plastic-associated chemicals.
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