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Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
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Weizmannia coagulans BC99 alleviates hyperuricemia and oxidative stress via DAF-16/SKN-1 activation in Caenorhabditis elegan
Frontiers in Microbiology
2024
5 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Ying Gao,
C C Li,
Junfei Li,
Ming Duan,
Xuan Li,
Lina Zhao,
Ying Wu,
Shaobin Gu
Summary
Researchers investigated whether the probiotic bacterium Weizmannia coagulans BC99 could alleviate hyperuricemia (high uric acid) and oxidative stress, testing in a C. elegans model and examining the DAF-16 signaling pathway. The probiotic reduced uric acid levels and extended lifespan in the model organism.
Models
These results underscore BC99 as an effective and economical adjunct therapeutic agent for hyperuricemia, providing a scientific basis for further development and application.