The Effects of Bisphenol A of Polycarbonate Plastics on Various Blood and Fertility Parameters, along with Histological Changes in Male Albino Rats

Background: Bisphenol A (BPA) is an essential monomer used in the manufacturing of polymers. They can bind to oestrogen receptors as agonists/antagonists, causing adverse effects on metabolic and endocrine system function. The current study aims to investigate the toxic effects of bisphenol A at various concentrations on male albino rats. Methods: Twenty male albino rats were equally divided into four groups [Gp1, control; Gp2, 25 mg/kg b.wt. of BPA; Gp3, 50 mg/kg b.wt. of BPA; Gp4, 100 mg/kg b.wt. of BPA], all groups were treated orally for 35 days. Result: Through the results, significant (P≤0.01) reductions were observed in the levels of sexual hormones (Testosterone (tt), Follicle-Stimulating Hormone (FSH) and Luteinizing (Hormone (LH) and Estrogen, for all groups dosed with BPA. Our results showed a significant (P≤0.01) decrease in the count of sperm, viability and sperm motility, for all groups dosed with BPA in contrast to the group under control. Bisphenol A at different doses leads to a significant (P≤0.01) increase in liver enzymes (AST and ALT) for all treated groups in contrast to the group under control, with various histological changes in the liver, including multiple severe fibrosis of the portal area and multiple sever portal amyloidosis and congestion with fibro portal extension to neighboring areas.