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Toxicity of micromilimeter of polyvinly chloride and polystyrene sulfonic acid microplastics toward NCM460 cells
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PVC and polystyrene sulfonic acid microplastics were tested on NCM460 human colonic epithelial cells at varying concentrations and exposure times, with CCK-8 assay results showing PS to be less toxic than PVC to intestinal cells—providing experimental evidence for differential intestinal risk assessment of these common polymers.
To investigate the difference in toxicity between polyvinyl chloride (PVC) and polystyrene sulfonic acid (PS), this study tests the toxicity of PVC and PS on NCM460 cells. NCM460 cells are located in the human colonic epithelium. By testing these two different microplastics at various concentrations and exposure times (e.g., 2 hours and 24 hours), the CCK-8 assay results show that PS is a safer material for intestinal cells than PVC. This work provides theoretical and experimental evidence for evaluating the risk of microplastics to intestinal cells.
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This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
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Researchers tested the toxic effects of polystyrene microplastics on human colorectal cells in the laboratory and found that both 80-nanometer and 500-nanometer particles significantly reduced cell viability and induced programmed cell death. The effects were size- and concentration-dependent, with smaller particles generally causing greater toxicity, providing experimental evidence for evaluating the intestinal health risks of microplastic exposure.
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