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Polypropylene Micro- and Nanoplastics Affect the Digestion of Cow's Milk Proteins in Infant Model of Gastric Digestion
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Researchers developed a simplified in vitro digestion protocol to better simulate how micro- and nanoplastics are biotransformed during human digestion, enabling more realistic cytotoxicity testing and risk assessment of plastic ingestion compared to prior models.
Gastric and Gastrointestinal Digestion of Infant Formula in the Presence of Polypropylene Nanoplastics
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Researchers investigated how polypropylene nanoplastics at concentrations of 10–100 μg/mL affect the in vitro digestion of infant formula proteins, finding that nanoplastic agglomeration interfered with protein digestibility in simulated gastric and intestinal conditions relevant to infant feeding bottle exposure.
Polypropylene micro- and nanoplastics affect the digestion of cow's milk proteins in infant model of gastric digestion
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Researchers found that polypropylene micro- and nanoplastics, commonly released from baby bottles during heating, interfere with the digestion of milk proteins in a simulated infant stomach model. The plastic particles bound to milk proteins and changed how they were broken down by digestive enzymes, with the effect being stronger in the infant model than in the adult model. This is concerning because incomplete protein digestion in infants could affect nutrient absorption during a critical period of growth and development.
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Researchers reviewed how microplastics and nanoplastics enter the human body through food and drink, finding that the tiniest particles likely penetrate the gut lining and enter tissues in ways similar to drug-delivery nanoparticles. This raises significant concerns about long-term health effects from everyday dietary exposure to plastic contamination.
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This review examined how micro- and nanoplastics disrupt gut microbiota and immune function across aquatic and terrestrial vertebrates, with implications for human health. Because the gut microbiome governs immune regulation and metabolic health, microplastic-induced dysbiosis represents a plausible mechanism by which plastic ingestion could drive systemic inflammation and disease beyond the GI tract.
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