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Human Ingestion of Micro-/Nanoplastics: A Simplified In Vitro Digestion Protocol for Cytotoxicity and Risk Assessment

Methods and protocols in food science 2026
Verónica Bastos, H. S. M. Oliveira

Summary

Researchers developed a simplified in vitro digestion protocol to better simulate how micro- and nanoplastics are biotransformed during human digestion, enabling more realistic cytotoxicity testing and risk assessment of plastic ingestion compared to prior models.

Study Type In vitro

A comprehensive risk assessment of plastics’ health impacts is imperative; however, significant gaps exist in toxicity models that closely simulate human ingestion. The biotransformation of micro−/nanoplastics (MNPLs) during the digestion process, along...

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