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Emerging microplastic and nanoplastic threats: Decoding winter survival mechanisms in hybrid groupers through hepatic metabolic disruption

Environmental Chemistry and Ecotoxicology 2025 1 citation ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 53 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Hengxiang Li, Xiang‐Rong Xu Julie B. Wang, Xiang‐Rong Xu Lang Lin, Julie B. Wang, Lang Lin, Xiang‐Rong Xu Lang Lin, Lang Lin, Lang Lin, Yan Gao, Rui Hou, Rui Hou, Xiang‐Rong Xu Xiang‐Rong Xu Lang Lin, Hengxiang Li, Hengxiang Li, Lang Lin, Hengxiang Li, Hengxiang Li, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Hengxiang Li, Hengxiang Li, Xiang‐Rong Xu Xiang‐Rong Xu Lang Lin, Lang Lin, Lang Lin, Shanshan Yao, Lang Lin, Shanshan Yao, Xiang‐Rong Xu Hengxiang Li, Lang Lin, Hengxiang Li, Lang Lin, Xiang‐Rong Xu Lang Lin, Lang Lin, Hengxiang Li, Lang Lin, Hengxiang Li, Hengxiang Li, Lang Lin, Lang Lin, Lang Lin, Hengxiang Li, Hengxiang Li, Hengxiang Li, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Hengxiang Li, Hengxiang Li, Hengxiang Li, Hengxiang Li, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Shan Liu, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Lang Lin, Xiang‐Rong Xu Rui Hou, Hengxiang Li, Xiang‐Rong Xu Hengxiang Li, Lang Lin, Lang Lin, Xiang‐Rong Xu Xiang‐Rong Xu Lang Lin, Lang Lin, Xiang‐Rong Xu Xiang‐Rong Xu Hengxiang Li, Hengxiang Li, Hengxiang Li, Rui Hou, Lang Lin, Rui Hou, Rui Hou, Rui Hou, Rui Hou, Xiang‐Rong Xu Lang Lin, Xiang‐Rong Xu Lang Lin, Xiang‐Rong Xu Lang Lin, Xiang‐Rong Xu Rui Hou, Hengxiang Li, Lang Lin, Xiang‐Rong Xu Hengxiang Li, Rui Hou, Hengxiang Li, Hengxiang Li, Rui Hou, Hengxiang Li, Shan Liu, Lang Lin, Lang Lin, Shan Liu, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Hengxiang Li, Shan Liu, Rui Hou, Rui Hou, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Rui Hou, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Zhijian Jiang, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Lang Lin, Xiang‐Rong Xu Xiang‐Rong Xu Lang Lin, Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Xiang‐Rong Xu Hengxiang Li, Xiang‐Rong Xu Xiang‐Rong Xu Zhijian Jiang, Xiang‐Rong Xu Hengxiang Li, Xiang‐Rong Xu

Summary

Researchers explored how microplastics and nanoplastics of varying sizes affect hepatic lipid metabolism in hybrid grouper fish during winter overwintering periods. The study found that polystyrene particles disrupted lipid metabolism, caused oxidative stress, and altered gene expression in liver tissue, suggesting these pollutants may compromise fish survival during metabolically demanding cold seasons.

Polymers

Body Systems

Hepatic Immune

This study explores the impact of microplastics (MPs) and nanoplastics (NPs) on hepatic lipid metabolism in pearl gentian grouper ( Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) during overwintering and elucidates the underlying mechanisms. Fish were exposed to polystyrene (PS) MPs and NPs of varying sizes (5 μm, 500 nm, and 50 nm) for a 15-day exposure period. Histopathological analysis, oxidative stress assessment, and gene expression profiling related to lipid metabolism revealed significant toxic effects on the liver. Results showed that NPs preferentially accumulated in the liver, causing hepatocyte swelling, inflammation, and lipid metabolism disorders. Smaller particle sizes intensified oxidative stress, reduced triglyceride (TG) content, and elevated low-density lipoprotein cholesterol (LDL-C) and total cholesterol (T-CHO) levels. Transcriptomic analysis indicated that MPs and NPs altered the expression of lipid metabolism genes, particularly those in glyceride metabolism and lipolysis pathways, with significant upregulation of PNPLA2 and LIPG ( p < 0.05) under cold stress. This led to excessive energy reserve depletion and hepatic lipid metabolism dysfunction. This study establishes a “environmental stress-gene-metabolism” response model and provides novel insights into the molecular mechanisms by which NPs disrupt lipid homeostasis in aquatic organisms, offering a theoretical basis for understanding the toxicological effects of emerging contaminants. • Liver was the main target organ for NPs action. • Size effect adjusted oxidative stress in liver. • MPs and NPs promoted lipid depletion in the liver at low temperatures. • MPs and NPs interfered with lipid metabolism in liver.

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