We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Aging amplifies the combined toxic effects of polystyrene nanoplastics and norfloxacin on human intestinal cells
Summary
Researchers investigated how environmental aging of polystyrene nanoplastics affects their combined toxicity with the antibiotic norfloxacin on human intestinal cells. They found that aged nanoplastics were taken up more readily by cells and significantly amplified the harmful effects of the antibiotic, including increased cell damage. The study suggests that weathered nanoplastics in the environment may pose greater health risks than fresh particles, especially when combined with other contaminants.
Photo-Fenton-like aging accurately mimics PS-NPs' natural sunlight exposure. A photostable AIE dye enables precise intracellular quantification, solving a key analytical challenge. Aging enhances PS-NPs/NOR co-exposure cytotoxicity in Caco-2 cells.
Sign in to start a discussion.
More Papers Like This
Enhanced biotoxicity by co-exposure of aged polystyrene and ciprofloxacin: the adsorption and its influence factors
This study found that polystyrene microplastics aged by sunlight absorbed significantly more of the antibiotic ciprofloxacin than fresh microplastics, and the combination was more toxic to organisms than either pollutant alone. The aging process created more surface area and chemical binding sites on the plastic particles. This is important because it means weathered microplastics in the real world can concentrate antibiotics and deliver higher toxic doses to organisms, potentially contributing to both direct toxicity and antibiotic resistance.
Amplified toxic effects of nanoplastic composite norfloxacin on liver cells in mice: Mechanistic insights and multiscale evaluation
Researchers examined the combined toxic effects of nanoplastics and the antibiotic norfloxacin on mouse liver cells and found that co-exposure was significantly more harmful than either contaminant alone. The nanoplastics acted as carriers that increased antibiotic accumulation inside cells, amplifying oxidative damage and disrupting key protective enzymes. The study highlights that nanoplastics in the environment can worsen the toxicity of co-occurring pollutants like antibiotics.
Aged microplastics enhance their interaction with ciprofloxacin and joint toxicity on Escherichia coli
Researchers found that aged microplastics showed enhanced adsorption of the antibiotic ciprofloxacin compared to pristine particles, and that their combined exposure produced greater toxicity to E. coli at the molecular level than either pollutant alone.
Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways
Researchers co-exposed rats to polystyrene nanoplastics and the antibiotic gentamicin and found that the combination caused significantly greater kidney damage than either substance alone, amplifying oxidative stress, inflammation, and mitochondrial apoptosis in a synergistic manner.
The neurodevelopmental toxicity induced by combined exposure of nanoplastics and penicillin in embryonic zebrafish: The role of aging processes
Researchers studied how nanoplastics combined with the antibiotic penicillin affect brain development in zebrafish embryos, including how aging of the nanoplastics changes their toxicity. They found that pristine and UV-aged nanoplastics combined with penicillin caused more severe neurodevelopmental harm than either substance alone, suppressing heartbeat and movement. The findings suggest that environmental aging of nanoplastics can alter their interactions with common pollutants like antibiotics, potentially increasing risks to developing organisms.