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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Detection Methods Gut & Microbiome Human Health Effects Nanoplastics Sign in to save

Aging amplifies the combined toxic effects of polystyrene nanoplastics and norfloxacin on human intestinal cells

Environmental Science Nano 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Long Zhang, Xi Deng, Zhi Qin, Xiaoqi Guo, Chenxi Wang, Jie Tang

Summary

Researchers investigated how environmental aging of polystyrene nanoplastics affects their combined toxicity with the antibiotic norfloxacin on human intestinal cells. They found that aged nanoplastics were taken up more readily by cells and significantly amplified the harmful effects of the antibiotic, including increased cell damage. The study suggests that weathered nanoplastics in the environment may pose greater health risks than fresh particles, especially when combined with other contaminants.

Polymers
PS

Photo-Fenton-like aging accurately mimics PS-NPs' natural sunlight exposure. A photostable AIE dye enables precise intracellular quantification, solving a key analytical challenge. Aging enhances PS-NPs/NOR co-exposure cytotoxicity in Caco-2 cells.

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