A quality-by-design inspired approach to develop PET and PP nanoplastic test materials for use in in vitro and in vivo biological assays

Lukas Wimmer; Manh Hoang; Jacqueline Schwarzinger; Vesna Jovanović; Boban Anđelković; Tanja Ćirković Veličković; Thomas Meisel; Tassilo Waniek; Christiane Weimann; Korinna Altmann; Lea Ann Dailey

doi:10.1039/d4en01186d

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A quality-by-design inspired approach to develop PET and PP nanoplastic test materials for use in in vitro and in vivo biological assays

Environmental Science Nano 2025 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.

Lukas Wimmer, Manh Hoang, Jacqueline Schwarzinger, Vesna Jovanović, Boban Anđelković, Tanja Ćirković Veličković, Thomas Meisel, Tassilo Waniek, Christiane Weimann, Korinna Altmann, Lea Ann Dailey

Summary

Researchers developed a quality-by-design approach for producing standardized PET and polypropylene nanoplastic test materials suitable for biological assays. The study provides a systematic framework for generating consistent nanoplastic particles for use in both in vitro and in vivo toxicity studies.