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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Marine & Wildlife Nanoplastics Remediation Sign in to save

Effects of Sub-Chronic Exposure to Polystyrene Nanoplastics on Lipid and Antioxidant Metabolism in Sparus aurata

Animals 2025 4 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 58 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Hayam Djafar, Ekemini Moses Okon, Ekemini Moses Okon, Juan Balasch, I. Brandts, I. Brandts, I. Brandts, I. Brandts, I. Brandts, Hayam Djafar, I. Brandts, I. Brandts, I. Brandts, Mariana Teles I. Brandts, Mariana Teles I. Brandts, I. Brandts, Juan Balasch, Juan Balasch, Juan Balasch, Mariana Teles Juan Balasch, Juan Balasch, I. Brandts, I. Brandts, Asta Tvarijonaviciute, I. Brandts, I. Brandts, Mariana Teles I. Brandts, I. Brandts, Hayam Djafar, Asta Tvarijonaviciute, Hayam Djafar, Asta Tvarijonaviciute, I. Brandts, I. Brandts, Asta Tvarijonaviciute, Asta Tvarijonaviciute, I. Brandts, Juan Balasch, Juan Balasch, Mariana Teles Asta Tvarijonaviciute, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Mariana Teles Juan Balasch, Mariana Teles Mariana Teles I. Brandts, Asta Tvarijonaviciute, Mariana Teles Mariana Teles Asta Tvarijonaviciute, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Mariana Teles Mariana Teles Asta Tvarijonaviciute, Mariana Teles Mariana Teles Asta Tvarijonaviciute, Mariana Teles Mariana Teles Mariana Teles Mariana Teles Mariana Teles Mariana Teles Mariana Teles Juan Balasch, Mariana Teles Mariana Teles Mariana Teles Mariana Teles Mariana Teles

Summary

Researchers exposed gilthead seabream to polystyrene nanoplastics for 14 days and measured effects on blood, tissue, and gene expression. While the fish showed no visible tissue damage or changes in body condition, they had reduced hemoglobin levels and significant downregulation of genes related to fat metabolism, growth, and antioxidant defense. The study suggests that nanoplastics can cause subtle but meaningful biological changes in fish even when outward signs of harm are absent.

Polymers
PS
Body Systems
Hematopoietic Hepatic Immune

Nanoplastics (NPs) can cross cellular membranes and affect cellular performance. This study aims to determine the effects of polystyrene NPs (PS-NPs, 44 nm) on gilthead seabream (<i>Sparus aurata</i>) exposed for 14 days to 100 μg/L PS-NPs. The results show that biometric indicators (weight, length, Fulton's condition factor, and hepatosomatic index) were not affected after the experimental exposures. No significant effects were observed on white blood cell count, red blood cell count, mean corpuscular hemoglobin, or platelets compared to the control group. However, there was a significant decrease in hemoglobin concentration, hematocrit values, and mean corpuscular cell volume in fish exposed to PS-NPs. There were no significant effects on plasmatic cholesterol, triglyceride, alkaline phosphatase, or aspartate aminotransferase levels. The histological anatomy of both the gills and the intestine revealed no obvious signs of cellular damage, excessive mucous, or inflammation in the PS-NP group. The expression of transcripts related to lipid metabolism (<i>pparα</i>, <i>pparβ</i>), growth and development (<i>igf1</i>), detoxification (<i>bche</i>), and oxidative stress (<i>sod</i>, <i>gpx1</i>) were significantly downregulated in animals exposed to PS-NPs, indicating a slight impairment in lipid homeostasis and antioxidant response.

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