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Organ-Specific Effects of Polystyrene Nanoplastics on Deltamethrin-Induced Toxicity in Mice: Mitigated Hepatorenal Oxidative Damage But Increased Enteric Toxicity
Summary
Researchers studied how nanoplastics combined with the pesticide deltamethrin affect different organs in mice. They found that nanoplastics actually reduced pesticide-related damage in the liver and kidneys but increased toxicity in the intestines by trapping more pesticide there and disrupting gut bacteria. The study reveals that nanoplastics can shift where pesticide damage occurs in the body, creating unexpected health risks in the digestive system.
This study investigates the combined effects of polystyrene nanoplastics (PS-NPs) and deltamethrin (DEL) on mice, focusing on their different impacts among organs. Mice were exposed to PS-NPs and/or DEL for 30 days. Results showed that PS-NPs alleviated DEL-induced oxidative damage in the liver and kidney by reducing its accumulation due to decreased bioaccessibility. Conversely, PS-NPs increased DEL accumulation in the intestine, leading to enhanced susceptibility to enteric infections caused by bacteria, viruses, and parasites, as indicated by transcriptomic analysis. PS-NPs delayed DEL excretion by reducing gastrointestinal motility, as evidenced by altered neurotransmitter levels, thereby contributing to greater intestinal accumulation of DEL. Moreover, 16S rDNA sequencing revealed that PS-NPs tended to decrease beneficial bacteria and increase pathogenic bacteria in the gut microbiota, further heightening susceptibility to enteric infections upon coexposure. The findings of this study shed new light on the complex health risks associated with coexposure to nanoplastics and pesticides.