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Potential synergistic effects of microplastics and zinc oxide nanoparticles: biochemical and physiological analysis on Astacus leptodactylus

Ecotoxicology 2025 10 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 68 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Mahdi Banaee, Cristiana Roberta Multisanti, Cristiana Roberta Multisanti, Amin Gholamhosseini, Amin Gholamhosseini, Amir Zeidi, Amir Zeidi, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Caterina Faggio Mahdi Banaee, Caterina Faggio Mahdi Banaee, Cristiana Roberta Multisanti, Cristiana Roberta Multisanti, Amin Gholamhosseini, Reza Shakeri, Caterina Faggio Amin Gholamhosseini, Amin Gholamhosseini, Mahdi Banaee, Amir Zeidi, Amir Zeidi, Caterina Faggio Caterina Faggio Cristiana Roberta Multisanti, Amin Gholamhosseini, Amin Gholamhosseini, Amin Gholamhosseini, Amin Gholamhosseini, Amin Gholamhosseini, Amin Gholamhosseini, Cristiana Roberta Multisanti, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Mahdi Banaee, Amir Zeidi, Cristiana Roberta Multisanti, Mahdi Banaee, Caterina Faggio Caterina Faggio Caterina Faggio Cristiana Roberta Multisanti, Cristiana Roberta Multisanti, Amin Gholamhosseini, Caterina Faggio Mahdi Banaee, Caterina Faggio Amin Gholamhosseini, Mahdi Banaee, Caterina Faggio Reza Shakeri, Mahdi Banaee, Amin Gholamhosseini, Mahdi Banaee, Mahdi Banaee, Cristiana Roberta Multisanti, Mahdi Banaee, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Cristiana Roberta Multisanti, Caterina Faggio Caterina Faggio Caterina Faggio Amin Gholamhosseini, Amin Gholamhosseini, Amir Zeidi, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Cristiana Roberta Multisanti, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Cristiana Roberta Multisanti, Cristiana Roberta Multisanti, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Mahdi Banaee, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio

Summary

Researchers exposed crayfish to microplastics and zinc oxide nanoparticles, both alone and combined, and found that the combination caused greater harm than either pollutant on its own, including increased liver stress markers and reduced antioxidant defenses. These findings suggest that microplastics may make other common environmental pollutants more toxic when they occur together in waterways that supply food and drinking water.

Polymers

PE PS PVC

The present study aimed to evaluate the effects of microplastics (MPs) and Zinc Oxide nanoparticles (ZnO-NPs), both individually and in combination, on the crayfish, Astacus leptodactylus. A total of 360 crayfish were assigned to eight experimental groups, including control and treatment groups exposed to MPs (polyethylene, polystyrene, and polyvinyl chloride at 300 µg/L) and ZnO-NPs (5 µg/L), individually and combined. Biochemical analyses on the haemolymph revealed a significant increase in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamic transpeptidase activities, and glucose and cholesterol levels in crayfish exposed to MPs and ZnO-NPs. In contrast, butyrylcholinesterase activity was significantly decreased in all treatments compared to the control. Lactate dehydrogenase activity increased significantly in crayfish exposed to ZnO-NPs, alone or combined with MPs. Furthermore, thiol groups, total antioxidant levels, and glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase were significantly decreased, while malondialdehyde levels were increased. The integrated biomarker response (IBR) and radar plots highlighted a cumulative oxidative stress response, suggesting potential synergistic or additive interactions between MPs and ZnO-NPs.

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