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Review for "Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes"
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Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes
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In a mouse study, polystyrene microplastics caused thyroid dysfunction by altering gene expression, increasing oxidative stress, and damaging thyroid tissue. The findings show that microplastic exposure can disrupt the endocrine system, specifically the thyroid gland which controls metabolism and development. As environmental microplastic contamination increases, this research raises concerns about potential thyroid-related health problems in both animals and humans.
Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment
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Researchers investigated the effects of polystyrene nanoplastics on thyroid-derived cell lines, finding rapid intracellular uptake, disruption of redox balance, and altered expression of thyroid hormone-related genes and proteins. The findings indicate that nanoplastics can directly disrupt thyroid cell function through oxidative stress and interference with hormone biosynthesis pathways.
Unraveling the endocrine disruption potential of microplastics in testosterone regulation
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Researchers reviewed in vivo evidence that microplastics impair testosterone synthesis through multiple converging mechanisms — oxidative damage to Leydig cells, disruption of the LH/cAMP/StAR steroidogenesis cascade, NF-κB inflammation, and endoplasmic reticulum stress — while flagging a critical gap in human data and the largely unexplored role of physicochemical diversity among plastic types.
Small particles, big impact: A narrative review of microplastics and their effects on thyroid function
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This narrative review synthesized evidence linking microplastic and nanoplastic exposure to thyroid dysfunction, examining mechanisms including endocrine disruption, oxidative stress, and immune dysregulation. The authors identified thyroid-disrupting effects in both animal models and human epidemiological data, with children and pregnant women as particularly vulnerable populations.
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