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Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes
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In a mouse study, polystyrene microplastics caused thyroid dysfunction by altering gene expression, increasing oxidative stress, and damaging thyroid tissue. The findings show that microplastic exposure can disrupt the endocrine system, specifically the thyroid gland which controls metabolism and development. As environmental microplastic contamination increases, this research raises concerns about potential thyroid-related health problems in both animals and humans.
These findings underscore the potential risks that PS-MPs pose to thyroid health, with potential consequences for other veterinary species. As environmental contamination rises, veterinarians may encounter more endocrine disorders linked to PS-MPs, emphasising the need for further research and preventive measures.
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Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment
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Researchers investigated the effects of polystyrene nanoplastics on thyroid-derived cell lines, finding rapid intracellular uptake, disruption of redox balance, and altered expression of thyroid hormone-related genes and proteins. The findings indicate that nanoplastics can directly disrupt thyroid cell function through oxidative stress and interference with hormone biosynthesis pathways.
Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics
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Adult male rats were given daily oral doses of polystyrene nanoplastics for five weeks, causing dose-dependent reductions in thyroid hormone levels (T3, T4, FT3, FT4) and increases in TSH, along with elevated oxidative stress markers. The study provides evidence that chronic nanoplastic ingestion disrupts the thyroid endocrine system in a mammalian model.
Reproductive Toxicity of Chronic Exposure To Polystyrene Microplastics And The Molecular Mechanism of Decrease In Testosterone Levels In Male Mice
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Chronic exposure to polystyrene microplastics lowered testosterone levels in male mice and disrupted reproductive organ function. The study identified molecular pathways through which microplastics interfere with male hormone production, with implications for reproductive health in humans exposed through diet.
Repeated oral exposure to polyethylene microplastics induces thyroid toxicity in rats: Evidence from in vivo toxicokinetics and multi-omics analyses
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Rats fed microplastics daily for 28 days developed thyroid problems, including lower thyroid hormone levels and swelling in thyroid tissue, at doses just 10 to 100 times higher than what people are estimated to consume daily. The plastic particles built up in organs and disrupted genes tied to thyroid function. This early evidence suggests everyday plastic exposure could affect thyroid health, though more research is needed to confirm risks in humans.
Nano and microplastics: unveiling their profound impact on endocrine health
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This review summarizes existing research showing that micro- and nanoplastics can disrupt the endocrine (hormone) system, altering reproductive hormones, thyroid function, and gene expression in lab and animal studies. Exposure to these particles triggered inflammation markers and oxidative stress in hormone-producing organs, suggesting that widespread plastic pollution may be contributing to rising rates of hormonal and reproductive health problems.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.