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Metadata for Polyethylene Terephthalate Microplastics Study
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This record is a dataset, not a full study, containing raw measurements from animals used in a related publication on a single oral dose of polyethylene terephthalate microplastics. The original study examined mild metabolic and gastrointestinal effects, noting differences by dose amount and sex.
It contains the raw values for endpoints for individual animals within treatment groups that are reported in tables and figures. This dataset is associated with the following publication: Lewis, A., A. Biales, C. Miller, W. Oshiro, T. Beasley, M. Schladweiler, G. Momplaisir, B. Flick, M.J. See, R. Huang, W. Williams, M. Moore, G. Casuccio, L. Li, M. Deible, R. Grindstaff, T. Jackson, M. Hazari, K. Rogers, K. Ho, and A. Farraj. A Single Oral Exposure to Polyethylene Terephthalate Microplastics Causes Mild Metabolic and Gastrointestinal Disruption: Dose and Sex as Effect Modifiers. DRUG AND CHEMICAL TOXICOLOGY. Marcel Dekker Incorporated, New York, NY, USA, 1-18, (2026).
More Papers Like This
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
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Researchers gave male and female rats a single oral dose of PET microplastics at 5 or 50 mg/kg and monitored metabolic rate, respiratory exchange ratio, and tissue gene expression for 18 hours, finding sex- and dose-dependent disruptions including decreased metabolic rate, altered duodenal gene expression in males, and increased serum LDL in females, suggesting mild but measurable metabolic and gastrointestinal effects.
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
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Researchers gave male and female rats a single oral dose of PET microplastics derived from cryomilled nurdles and monitored metabolic rate, gene expression, and blood biomarkers for 18 hours, finding sex- and dose-dependent effects including decreased metabolic rate, altered duodenal gene expression in males, and elevated LDL in females, suggesting mild but measurable systemic disruption.
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants
AI summary Read the abstract
Researchers gave male and female rats a single oral dose of PET microplastics derived from cryomilled nurdles and monitored metabolic rate, gene expression, and blood biomarkers for 18 hours, finding sex- and dose-dependent effects including decreased metabolic rate, altered duodenal gene expression in males, and elevated LDL in females, suggesting mild but measurable systemic disruption.
The Effect of Polyethylene Terephthalate Microplastics on the Growth of Mice
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Mice were fed diets containing 0, 300, or 600 ug PET microplastics for an experimental period to examine effects on body weight, feces weight, and feed consumption. Food contaminated with microplastics altered growth metrics compared to controls, raising concerns about dietary microplastic exposure effects on mammalian health.
Toxicological Evaluations Following 28-Day Oral Gavage Exposure to Polyethylene Terephthalate Microplastic Particles in Mice
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Mice were fed PET microplastics daily for 28 days at different doses. No major health effects showed up in body weight, blood tests, or organ weights, but male mice had minor kidney changes and both sexes showed fewer gut goblet cells, without visible damage to the gut lining.
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