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Code and derived data for: Comparative transcriptomics identifies shared interferon enrichment and context-dependent metabolic responses in polystyrene nanoplastic-exposed microglia
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This is a data and code release supporting a study that compared gene activity in microglia, a type of brain cell, exposed to polystyrene nanoplastics across multiple public datasets. It includes analysis scripts, gene reference files and figure data, but no new experiments or statistical analyses were run for this release.
License scope: MIT applies to original analysis code; CC BY 4.0 applies to original derived data and documentation. Third-party materials retain their original terms, as detailed in THIRD_PARTY_NOTICES.txt. The CollecTRI resource TSV and cleaned interaction network are excluded from the public archive; provider guidance and expected checksums are supplied. Exact historical regulatory-analysis reproduction requires a lawfully accessible matching snapshot. STRING input files and primary sequencing/count inputs must also be obtained separately. This deposit contains selected source data; the supplementary Excel workbooks remain supplied with the manuscript. No statistical analyses were rerun when preparing this release. Reproducibility resources accompanying the manuscript 'Comparative transcriptomics identifies shared interferon enrichment and context-dependent metabolic responses in polystyrene nanoplastic-exposed microglia'. The resources include analysis scripts, frozen gene definitions, archived orthology mappings and query records, software environment records, selected figure source data, matched-null analyses and donor-influence outputs. Analyses use public GEO studies GSE243612, GSE262029, GSE255658, GSE264018, GSE160012, GSE299749, GSE173173 and GSE249315. No new primary sequencing data were generated. Raw sequencing/count inputs are obtained from the cited public sources; historical paths in archived scripts require local adaptation. The single-cell contextual projection corresponds to Supplementary Figure S8. Third-party resources retain their own licenses; they are not relicensed by this deposit.
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