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Intestine - Oxidative Stress after PS-NPs exposure
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Scientists found that tiny plastic particles (nanoplastics) can build up in the gut lining of young rats, causing oxidative stress, a kind of cellular damage, along with inflammation and disruptions to the gut's normal balance. This matters because our guts are constantly exposed to microplastics from food and water, and this study suggests these particles could harm gut health, especially in developing bodies, though more research is needed to confirm this happens in humans.
This repository contains part of the data associated with the article “Nanoplastic Disrupts Intestinal Homeostasis in Immature Rats by Altering the Metabolite Profile and Gene Expression.” The repository includes data related to confocal microscopy imaging of intestinal tissue, including images of intestinal sections and analysis of the fluorescence intensity of PS-NPs. It also contains data on oxidative stress markers, including protein carbonyl groups, malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione (GSH) concentration. In addition, the repository provides data on the activity of antioxidant enzymes, including catalase (CAT) and superoxide dismutase (SOD). Western blot (WB) analysis is also included, together with the corresponding images and quantitative results for CAT, IL-1B, SOD1, SOD2, and TNF. Furthermore, the repository contains PCR data on the expression of three antioxidant enzymes: CAT, SOD1, and SOD2. Overall, these data provide supporting experimental results related to PS-NPs accumulation, oxidative stress, antioxidant defense, inflammation, and alterations in intestinal homeostasis in immature rats.
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This review summarizes research on how micro- and nanoplastics affect the gut, finding that they can damage the intestinal lining, trigger immune responses, and disrupt the balance of beneficial gut bacteria in both cell studies and animal models. Since humans are primarily exposed to microplastics through food and food packaging, understanding these gut effects is essential for assessing the true health risks of plastic pollution.
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This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
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Scientists fed mice tiny plastic particles daily for two months and found real damage to the gut, especially in the lower intestine, including changes in immune response and the barrier that keeps things from leaking through intestinal walls. This is animal research, not proof of the same effect in humans, but it adds to concerns about how the nanoplastics found in everyday products might affect our digestive health over time.
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This review summarizes how micro- and nanoplastics can harm the digestive system by causing oxidative stress, inflammation, cell death, and disruption of gut bacteria. These connected pathways can damage the intestinal lining and may contribute to conditions like inflammatory bowel disease and colorectal cancer. The findings highlight the importance of understanding how everyday plastic exposure through food and water could affect gut health over time.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.