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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Nanoplastics Sign in to save

Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis

Particle and Fibre Toxicology 2025 4 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Huiwen Kang, Danyang Huang, Wei Zhang, Jingyu Wang, Ziyan Liu, Ziyan Wang, Guangyu Jiang, Ai Gao

Summary

Researchers found that polystyrene nanoplastic exposure in animals reduced levels of a gut-produced fatty acid called propionic acid, which in turn suppressed a heart-protective protein (FBP1) and led to cardiac injury — revealing a gut-to-heart pathway by which nanoplastic exposure may damage cardiovascular health.

Polymers
PS
Body Systems
Cardiovascular

In summary, our study systematically demonstrated the role of gut-heart axis in NPs-induced cardiac injury, and the specific process was that NPs exposure reduced propionate level, which in turn inhibited FBP1 expression to impair cardiac function. These findings provide new insights into NPs-induced cardiotoxicity and identifie potential therapeutic targets, providing clues for the prevention and treatment of NPs-induced cardiac injury in the future.

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