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In vivo Inhalation Toxicity of Polystyrene Nanoplastic Particles: PSLT-Like Responses of Apical Endpoints and Transcriptomic Changes

Research Square 2026
Emanoela Tha, Lan Ma‐Hock, Florian Gruenschlaeger, Taís Meziara Wilson, Varun Giri, Michael Eichenlaub, Wendel Wohlleben, Robert Landsiedel

Summary

Scientists tested how tiny plastic particles (nanoplastics) affect the lungs of animals when inhaled, since these particles are found in air and could potentially be breathed in by people. The good news: the plastic particles didn't cause unique or special harm—instead, they caused lung irritation similar to what happens when lungs get overloaded with any type of fine particle (like dust), suggesting the effects were mainly due to sheer particle buildup rather than something uniquely toxic about plastic itself. This matters because it suggests that at the levels tested, inhaled nanoplastics may pose risks similar to other inhaled particles

Polymers
Body Systems
Study Type In vivo

Overall, the concordance between exposure concentration, retained lung burden, apical responses, and transcriptomic changes supports a PSLT-like, overload-associated interpretation of the findings. The study did not provide evidence for a PS-specific mode of inhalation toxicity under the condi...

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