SAT-356 Bifidobacterium pseudolongum-derived inosine mitigates polystyrene nanoplastics-induced hepatic injury by inhibiting the polarization of M1 macrophages

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

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Tiny plastic particles from everyday exposure can damage the liver, and this mouse study found that they do so partly by wiping out a helpful gut bacterium and its byproduct, a molecule called inosine, that normally keeps liver inflammation in check. When researchers restored this bacterium or gave the mice inosine directly, it calmed down the inflammatory immune cells and protected the liver from plastic-related damage. While this research is still in the early animal-testing stage, it points to a promising future strategy—boosting specific gut bacteria—that could help protect our livers from the health effects of the microplastics we're increasingly ex

Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis

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The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.

Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus

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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.

Hydrogen micro-nano bubbles mitigate polystyrene microplastics-induced toxicity through gut microbiota composition and metabolic functions

Gauging the effects of a chronic exposure to polystyrene nanoplastics in the liver and intestine of Carassius auratus