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25 nm AuPS Pristine and Weathered Characterization and Triculture Tox
Summary
Scientists tested tiny plastic particles (like the microplastics found in food and water) before and after simulating sun exposure, using a lab model that mimics the human gut lining. They found that sunlight-aged plastic particles behaved differently than fresh ones when interacting with intestinal cells, suggesting that environmental weathering can change how microplastics affect our gut health—not just how much plastic we're exposed to, but its condition matters too. This research helps scientists better understand real-world risks, since the plastics we actually encounter in nature have often been broken down by sunlight, not fresh from the factory.
Physicochemical Characterization and Toxicity in a triculture transwell small intestinal epithelial model for pristine and UV-aged gold core-polystyrene shell (AuPS) nanoparticles, as published in Majumder et al., Impact of UV Aging on the Toxicity and Bioavailability of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-Traceable Core-Shell Polystyrene Nanoplastics in an In Vitro Triculture Small Intestinal Epithelium Model, 2025, Toxics. PMID: 41304491 PMCID: PMC12656232 DOI: 10.3390/toxics13110939