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Nanoplastics perturb extracellular vesicle-mediated communication in the in vitro and ex vivo bone marrow microenvironment of multiple myeloma
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Scientists found that tiny plastic particles (nanoplastics) can get inside bone marrow cells, including cancerous myeloma cells, causing stress and disrupting how these cells "talk" to each other through tiny messenger packets called extracellular vesicles. This disruption altered signals that normally help regulate bone-forming cells, suggesting that plastic pollution in our bodies could potentially interfere with healthy bone maintenance and possibly influence cancer-related processes in bone marrow. While this research was done in cells and animal models rather than in humans directly, it adds to growing concerns about how the microplastics and n
Nanoplastics (NPs) are emerging environmental contaminants capable of interacting with biological systems, yet their effects on intercellular communication in the bone marrow (BM) microenvironment remain unclear. This study investigated the impact of polystyrene NPs on extracellular vesicle (EV) biogenesis, cargo, and function using in vitro models of multiple myeloma (MM) and stromal cells, supported by ex vivo murine bone and human BM aspirates. Under the experimental conditions used in this study, NPs were efficiently internalized by both malignant and stromal cells, inducing oxidative stress and reducing cell viability. NP exposure altered EV biogenesis, leading to increased vesicle release, reduced size, and the incorporation of NPs into a subset of EVs. Additionally, EVs from NP-exposed MM cells showed decreased total miRNA content and modulation of miRNA sorting-related proteins. Among the analyzed miRNAs, miR-505, a candidate linked to osteogenic regulation, was reduced in both cells and EVs following NP exposure. Functionally, EVs from control MM cells downregulated osteogenic markers in pre-osteoblasts, whereas EVs from NP-exposed cells showed reduced regulatory effects. These findings demonstrate that NP exposure modifies EV-mediated signaling under experimental conditions, providing mechanistic insight into nanoplastic interference with BM cellular communication.
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Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
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Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
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This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
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This study examined how nanoplastics affect bone cell function in a murine model, investigating effects on osteoblasts and osteoclasts that govern bone formation and resorption in the bone microenvironment. Nanoplastic exposure altered bone cell activity, suggesting that daily plastic particle exposure could have long-term implications for bone health.
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
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This review explores the newly discovered relationship between microplastics and extracellular vesicles, tiny particles that cells use to communicate with each other. Evidence indicates that microplastics can alter how these vesicles are distributed and what molecular signals they carry, potentially disrupting normal cell communication. Understanding this interaction could provide important insights into how microplastic exposure may contribute to inflammation, metabolic changes, and other health effects.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells.
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Researchers investigated how nanoplastics affect the bone microenvironment using murine bone cell models, examining effects on osteoblast and osteoclast activity that regulate bone formation and resorption. Nanoplastic exposure disrupted bone cell function, raising concerns about skeletal health impacts from daily plastic particle exposure.
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