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The Copenhagen area Danish Structural Biology BAG
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A group of Danish university scientists is using powerful imaging techniques to see the 3D shapes of proteins and enzymes, which helps them understand how these molecules work at the atomic level. This detailed knowledge is being used to design better drugs to fight disease, create enzymes that could break down plastic pollution, and improve food safety—turning basic science into practical tools for real-world health and environmental problems.
The BAG gathers several danish groups at three Danish Universities in the greater Copenhagen area, using structural biology to answer a number of fundamental biological and protein-chemical questions ranging from detailed enzyme mechanisms to metal-guided folding of peptides. Many of our projects address issues of fundamental importance to society, from disease to food security to plastic pollution, which we address through eg. development of inhibitors and engineering of biocatalysts guided by our structure-function relationship studies. We also have several more fundamental studies for example determination of protonation states of functionally important residues from high resolution crystal structures.
More Papers Like This
The Copenhagen area Danish Structural Biology BAG
AI summary Read the abstract
A group of Danish universities is using powerful imaging tools to study the 3D shapes of proteins and enzymes, helping scientists understand how they work at a molecular level. This research has real-world payoffs: it's helping develop new drugs to fight disease, improve food security, and even engineer enzymes that could help break down plastic pollution. While not focused on human health directly, this foundational work supports future breakthroughs in medicine and environmental cleanup that could benefit us all.
The Copenhagen area Danish Structural Biology BAG
AI summary Read the abstract
Researchers at several Danish universities near Copenhagen used structural biology methods to study protein shapes and chemical mechanisms. Their projects relate to topics including disease, food security and plastic pollution, including work on designing enzymes that may break down plastic, based on studies of protein structure.
The Copenhagen area Danish Structural Biology BAG
AI summary Read the abstract
Researchers at Danish universities apply structural biology — including high-resolution crystallography and enzyme engineering — to problems spanning disease, food security, and plastic pollution, using structure-function relationships to design inhibitors and biocatalysts.
Engineering Plastic Eating Enzymes Using Structural Biology
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This review examines how structural biology approaches are being used to engineer plastic-degrading enzymes with improved efficiency and industrial scalability. Understanding the molecular interactions between enzymes and plastic substrates at an atomic level is guiding the design of more effective biocatalysts for plastic biodegradation.
From Bulk to Binding: Decoding the Entry of PET into Hydrolase Binding Pockets
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Researchers used molecular dynamics simulations and free energy analysis to decode the complete pathway by which PET polymer chains enter the binding pockets of plastic-degrading hydrolase enzymes at the atomic level. The study aims to deepen mechanistic understanding needed to guide protein engineering of PET hydrolases toward sufficient activity for industrial biocatalytic recycling.
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