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The Copenhagen area Danish Structural Biology BAG
Summary
A group of Danish university scientists is using powerful imaging techniques to see the 3D shapes of proteins and enzymes, which helps them understand how these molecules work at the atomic level. This detailed knowledge is being used to design better drugs to fight disease, create enzymes that could break down plastic pollution, and improve food safety—turning basic science into practical tools for real-world health and environmental problems.
The BAG gathers several danish groups at three Danish Universities in the greater Copenhagen area, using structural biology to answer a number of fundamental biological and protein-chemical questions ranging from detailed enzyme mechanisms to metal-guided folding of peptides. Many of our projects address issues of fundamental importance to society, from disease to food security to plastic pollution, which we address through eg. development of inhibitors and engineering of biocatalysts guided by our structure-function relationship studies. We also have several more fundamental studies for example determination of protonation states of functionally important residues from high resolution crystal structures.