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The Copenhagen area Danish Structural Biology BAG
Summary
Researchers at Danish universities apply structural biology — including high-resolution crystallography and enzyme engineering — to problems spanning disease, food security, and plastic pollution, using structure-function relationships to design inhibitors and biocatalysts.
The BAG gathers several danish groups at three Danish Universities in the greater Copenhagen area, using structural biology to answer a number of fundamental biological and protein-chemical questions ranging from detailed enzyme mechanisms to metal-guided folding of peptides. Many of our projects address issues of fundamental importance to society, from disease to food security to plastic pollution, which we address through eg. development of inhibitors and engineering of biocatalysts guided by our structure-function relationship studies. We also have several more fundamental studies for example determination of protonation states of functionally important residues from high resolution crystal structures.