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The Copenhagen area Danish Structural Biology BAG
Summary
A group of Danish universities is using powerful imaging tools to study the 3D shapes of proteins and enzymes, helping scientists understand how they work at a molecular level. This research has real-world payoffs: it's helping develop new drugs to fight disease, improve food security, and even engineer enzymes that could help break down plastic pollution. While not focused on human health directly, this foundational work supports future breakthroughs in medicine and environmental cleanup that could benefit us all.
The BAG gathers several danish groups at three Danish Universities in the greater Copenhagen area, using structural biology to answer a number of fundamental biological and protein-chemical questions ranging from detailed enzyme mechanisms to metal-guided folding of peptides. Many of our projects address issues of fundamental importance to society, from disease to food security to plastic pollution, which we address through eg. development of inhibitors and engineering of biocatalysts guided by our structure-function relationship studies. We also have several more fundamental studies for example determination of protonation states of functionally important residues from high resolution crystal structures.