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Raw individual behavioral, biochemical, neurochemical, and serum biomarker data from Swiss mice exposed to microplastics under contrasting climatic regimes
Summary
Scientists exposed mice to microplastics for a week under two different climate conditions—one realistic, one representing a worse future climate scenario—to see how heat and pollution together affect the body. They found that microplastics disrupted liver function, brain chemistry, and behavior differently depending on the climate scenario and whether the mice were male or female, suggesting that as our planet warms, plastic pollution's health risks might not stay the same. This matters because it hints that climate change could make microplastic exposure more (or differently) harmful to living bodies, including potentially ours, than lab studies done under "normal" conditions suggest.
This dataset contains the raw individual-level data used in the manuscript “CLIMATE-MODULATED PARTICLE TOXICITY: ACUTE EXPOSURE TO AN ENVIRONMENTALLY INFORMED MICROPLASTIC MIXTURE INDUCES SEX-DEPENDENT SYSTEMIC REORGANIZATION IN SWISS MICE”. The dataset includes behavioral, hepatic biochemical, brain neurochemical, serum biochemical, and hepatic microplastic accumulation data from young male and female Swiss mice exposed for 7 days to an environmentally informed microplastic mixture under two contrasting climatic regimes. Experimental groups include Control, MP-I, and MP-II, under realistic and pessimistic climatic scenarios. The file provides the absolute raw values used before index compilation and multivariate/network analyses, including hepatic oxidative stress and biotransformation biomarkers, brain acetylcholinesterase activity, colorimetric estimates of serotonin and dopamine, serum biochemical and endocrine markers, and open field behavioral scores. A data dictionary is included to describe each variable, experimental factor, and coding structure. These data support the transparency and reproducibility of the univariate analyses, composite indices, multivariate analyses, and network-based metrics reported in the manuscript.