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Extreme low-temperature exacerbates polystyrene microplastic-induced neuroendocrine and behavioral dysfunctions in female mice
Neurotoxicology and Teratology2025
2 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 58
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Alex Rodrigues Gomes,
Raíssa de Oliveira Ferreira,
Wesley Rodrigues Soares,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Liliana Ataides Silva Barichello,
Liliana Ataides Silva Barichello,
Liliana Ataides Silva Barichello,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Wesley Rodrigues Soares,
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Alex Rodrigues Gomes,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Liliana Ataides Silva Barichello,
Liliana Ataides Silva Barichello,
Liliana Ataides Silva Barichello,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Bruna de Oliveira Mendes,
Ariane Guimarães,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Ariane Guimarães,
Ariane Guimarães,
Ariane Guimarães,
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Alex Rodrigues Gomes,
Aline Sueli de Lima Rodrigues,
Aline Sueli de Lima Rodrigues,
Ariane Guimarães,
Ariane Guimarães,
Ariane Guimarães,
Ariane Guimarães,
Thiarlen Marinho da Luz,
Wesley Rodrigues Soares,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Raíssa de Oliveira Ferreira,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Guilherme Malafaia
Wesley Rodrigues Soares,
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Thiarlen Marinho da Luz,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Wesley Rodrigues Soares,
Thiarlen Marinho da Luz,
Wesley Rodrigues Soares,
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Thiarlen Marinho da Luz,
Wesley Rodrigues Soares,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Bruna de Oliveira Mendes,
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Bruna de Oliveira Mendes,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Ariane Guimarães,
Rafaela Ribeiro de Brito,
Ariane Guimarães,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Aline Sueli de Lima Rodrigues,
Ariane Guimarães,
Ariane Guimarães,
Ariane Guimarães,
Ariane Guimarães,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Ariane Guimarães,
Ariane Guimarães,
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Aline Sueli de Lima Rodrigues,
Thiarlen Marinho da Luz,
Alex Rodrigues Gomes,
Guilherme Malafaia
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Aline Sueli de Lima Rodrigues,
Alex Rodrigues Gomes,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Wesley Rodrigues Soares,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Thiarlen Marinho da Luz,
Rafaela Ribeiro de Brito,
Wesley Rodrigues Soares,
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Aline Sueli de Lima Rodrigues,
Aline Sueli de Lima Rodrigues,
Alex Rodrigues Gomes,
Guilherme Malafaia
Guilherme Malafaia
Alex Rodrigues Gomes,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Aline Sueli de Lima Rodrigues,
Rafaela Ribeiro de Brito,
Bruno da Cruz Pádua,
Aline Sueli de Lima Rodrigues,
Bruna de Oliveira Mendes,
Bruna de Oliveira Mendes,
Alex Rodrigues Gomes,
Bruno da Cruz Pádua,
Alex Rodrigues Gomes,
Alex Rodrigues Gomes,
Bruno da Cruz Pádua,
Ariane Guimarães,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Rafaela Ribeiro de Brito,
Thiarlen Marinho da Luz,
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Bruna de Oliveira Mendes,
Bruna de Oliveira Mendes,
Rafaela Ribeiro de Brito,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Guilherme Malafaia
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Guilherme Malafaia
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Bruna de Oliveira Mendes,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Ariane Guimarães,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Ariane Guimarães,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Bruno da Cruz Pádua,
Guilherme Malafaia
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Alex Rodrigues Gomes,
Bruna de Oliveira Mendes,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Thiarlen Marinho da Luz,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Raíssa de Oliveira Ferreira,
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Ariane Guimarães,
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Thiarlen Marinho da Luz,
Aline Sueli de Lima Rodrigues,
Guilherme Malafaia
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Alex Rodrigues Gomes,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Thiarlen Marinho da Luz,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Ariane Guimarães,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Guilherme Malafaia
Alex Rodrigues Gomes,
Guilherme Malafaia
Raíssa de Oliveira Ferreira,
Raíssa de Oliveira Ferreira,
Rafaela Ribeiro de Brito,
Guilherme Malafaia
Rafaela Ribeiro de Brito,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Wesley Rodrigues Soares,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Wesley Rodrigues Soares,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Bruno da Cruz Pádua,
Thiarlen Marinho da Luz,
Guilherme Malafaia
Alex Rodrigues Gomes,
Alex Rodrigues Gomes,
Alex Rodrigues Gomes,
Alex Rodrigues Gomes,
Alex Rodrigues Gomes,
Guilherme Malafaia
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Guilherme Malafaia
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Wesley Rodrigues Soares,
Guilherme Malafaia
Wesley Rodrigues Soares,
Guilherme Malafaia
Wesley Rodrigues Soares,
Guilherme Malafaia
Summary
Researchers studied how extreme cold temperatures combined with microplastic exposure affect the brains and behavior of female mice. They found that co-exposure caused increased anxiety, impaired memory, and disrupted key brain chemicals including dopamine and serotonin, with cold temperatures making the microplastic effects worse. The microplastics were also found lodged in fat tissue, where they caused oxidative stress and metabolic dysfunction that was amplified by the cold conditions.
Despite the growing recognition of the impacts of microplastics (MPs) and the intensification of extreme weather events, recent investigations have focused mainly on the consequences of global warming, while overlooking the potential impacts of extreme low-temperature (ELT) events and their interaction with these pollutants. Accordingly, the aim of this study was to assess the integrated effects of co-exposure to environmentally aged polystyrene microplastics (PS-MPs) and ELTs on behavioral, neuroendocrine, metabolic, and histomorphometric biomarkers in female Swiss mice. To this end, animals were orally exposed to environmentally aged PS-MPs (10 mg/kg/day) and maintained in a climate-controlled chamber at 4 °C for 21 days, whereas control groups were kept at 25 °C. In the behavioral domain, co-exposed animals exhibited increased locomotor disorganization, anxiety-like behavior, reduced exploratory efficiency, and impairments in memory and social discrimination, associated with neuroendocrine alterations involving dopamine, serotonin, epinephrine, and corticosterone, depending on the response evaluated. The retention of PS-MPs in the interscapular brown adipose tissue (iBAT) was confirmed by epifluorescence microscopy. It was associated with oxidative stress, decreased antioxidant defenses, and metabolic dysfunction in iBAT, effects exacerbated by ELT exposure. Multivariate analyses, including principal component analysis (PCA), Random Forest, and structural equation modeling (PLS-PM), revealed distinct phenotypic patterns among groups, as well as integrated causal trajectories linking neuroendocrine dysfunction to systemic phenotypic alterations. In conclusion, our study confirms the initial hypothesis by demonstrating that the combination of ELT and PS-MP ingestion amplifies systemic physiological dysfunctions beyond the effects of each individual stressor, highlighting the vulnerability of homeothermic mammals under multiple environmental pressures, and opening new perspectives for ecotoxicology to consider not only the impacts of global warming, but also the deleterious effects of ELTs in interaction with emerging pollutants.