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Raw individual behavioral, biochemical, neurochemical, and serum biomarker data from Swiss mice exposed to microplastics under contrasting climatic regimes
Summary
Scientists exposed mice to microplastic mixtures for a week under two different climate scenarios (normal vs. a hotter, harsher "pessimistic" future climate) to see how the plastics affected their bodies, brains, and behavior. The takeaway: microplastic toxicity isn't fixed—warmer, more extreme climate conditions appeared to change how the particles impacted the mice, and the effects differed between males and females. This matters because it suggests that as our climate changes, the health risks microplastics pose to living things—including potentially us—may shift too, making this an important area for continued research rather than a settled question.
This dataset contains the raw individual-level data used in the manuscript “CLIMATE-MODULATED PARTICLE TOXICITY: ACUTE EXPOSURE TO AN ENVIRONMENTALLY INFORMED MICROPLASTIC MIXTURE INDUCES SEX-DEPENDENT SYSTEMIC REORGANIZATION IN SWISS MICE”. The dataset includes behavioral, hepatic biochemical, brain neurochemical, serum biochemical, and hepatic microplastic accumulation data from young male and female Swiss mice exposed for 7 days to an environmentally informed microplastic mixture under two contrasting climatic regimes. Experimental groups include Control, MP-I, and MP-II, under realistic and pessimistic climatic scenarios. The file provides the absolute raw values used before index compilation and multivariate/network analyses, including hepatic oxidative stress and biotransformation biomarkers, brain acetylcholinesterase activity, colorimetric estimates of serotonin and dopamine, serum biochemical and endocrine markers, and open field behavioral scores. A data dictionary is included to describe each variable, experimental factor, and coding structure. These data support the transparency and reproducibility of the univariate analyses, composite indices, multivariate analyses, and network-based metrics reported in the manuscript.