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Investigation of the Effects of Hesperidin on Bisphenol-A Induced Neurotoxicity in Rats
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This study tests whether hesperidin, a naturally occurring flavonoid, can mitigate kidney damage caused by bisphenol A (BPA) exposure in an animal model. Findings indicate that hesperidin exerts a protective effect, likely through its antioxidant and anti-inflammatory properties, suggesting a potential dietary countermeasure to BPA-induced renal toxicity.
Bisphenol A (BPA) is an adhesive substance used in the production of food packaging, electronic devices, dental sealants and polycarbonate plastics. This substance, which can leak into products during industrial processes, can be taken into the body through contact or consumption. BPA causes oxidative damage in the body and toxicity to organs. This study was conducted on 52 male rats. The rats were randomly distributed into 4 separate groups, with 13 animals in each. Experiment groups were formed as follows: Control: 1 ml of olive oil was administered intragastrically for 14 days. Hesperidin (HESP): HESP was administered intragastrically at a dose of 50 mg/kg for 14 days. BPA: BPA dissolved in olive oil was administered intragastrically at a dose of 100 mg/kg for 14 days. BPA+HESP: BPA at a dose of 100 mg/kg and HESP at a dose of 50 mg/kg were administered intragastrically for 14 days. Brain tissue samples from the rats were collected on the 15th day of the experiment while the rats were under sevoflurane anesthesia. Histopathological and biochemical analyzes were performed on the brain tissues of the rats. As a result of the study, it was observed that HESP had a protective effect on BPA-induced neurotoxicity in rats and triggered the antioxidant mechanism responsible for defense in the cell. It was opined that the degenerative and necrotic tissue damage caused by BPA in the brain tissue decreased with the effect of Hesperidin.
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Researchers exposed albino rats to bisphenol A and then treated them with purple carrot extract, finding that the phytochemical-rich extract partially reversed BPA-induced neurotoxicity by modulating key neurotransmitters and cellular stress pathways, suggesting a potential dietary intervention against plastic chemical exposure.
Effect of bisphenol A on the neurological system: a review update
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This review summarizes recent research on how bisphenol A (BPA), a chemical found in many plastic products and food containers, affects the brain and nervous system. Studies show BPA exposure can cause oxidative stress, damage brain cells, disrupt neurotransmitters, and may increase the risk of neurological diseases like Alzheimer's and stroke. Children and developing fetuses appear to be especially vulnerable to BPA's harmful neurological effects.
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Researchers investigated the toxic effects of bisphenol A, a plastics-related endocrine disruptor, on common carp at different dose levels over 30 days. The study found dose-dependent reductions in blood cell counts, increased oxidative stress in the brain, liver, gills, and kidneys, and significant tissue damage, indicating that BPA exposure poses risks to aquatic organisms.
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This review examines how bisphenol A (BPA), a widespread industrial chemical found in polycarbonate plastics, disrupts endocrine function and neurological development, then evaluates biological, physical, and chemical remediation techniques — including membrane filtration, adsorption, and photocatalysis — for removing BPA from aqueous environments.
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