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20 resultsShowing papers similar to Unleashing multi-omic approaches to address environmental microplastic hazards in marine polychaetes
ClearMulti-omics characterisation of Daphnia magna exposed to PFAS and microplastics: transcriptome and gut microbiome datasets
Researchers generated a multi-omics dataset from Daphnia magna exposed to environmentally relevant concentrations of PFOS, PFOA, and PET microplastics, integrating gut microbiome 16S rRNA profiling and whole-organism transcriptomes to enable systems-level investigation of host-microbiome interactions under complex contaminant stress.
Multi stress system: Microplastics in freshwater and their effects on host microbiota
This study examined how combined exposure to microplastics and organic chemical pollutants affects freshwater organisms through a multi-stress approach, focusing on gut microbiome changes as an indicator. Microplastic exposure in combination with other pollutants altered microbiome composition more than either stressor alone, with potential consequences for host fitness and disease resistance.
Deciphering Gut Microbiome Responses upon Microplastic Exposure via Integrating Metagenomics and Activity-Based Metabolomics
Using advanced metagenomics and metabolomics techniques, researchers studied how polystyrene microplastic exposure affects the gut microbiome in mice. The study found that microplastics disrupted the balance of gut bacteria and altered metabolic pathways related to amino acids and lipids. These findings suggest that microplastic exposure could influence gut health and metabolism, though more research is needed to understand the implications for human health.
Impact of a chronic waterborne exposure to polystyrene nanoplastics on the gilthead seabream (Sparus aurata): Combining traditional and multi-omics approaches
Researchers exposed gilthead seabream to environmentally relevant and elevated polystyrene nanoplastic concentrations for 28 days, finding no visible tissue damage or blood abnormalities but significant shifts in gut microbiome diversity and dose-dependent changes in plasma metabolites linked to energy metabolism, suggesting subtle long-term risks for aquaculture production.
The effects of environmental Microplastic on wharf roach (Ligia exotica): A Multi-Omics approach
Wild wharf roaches collected from a microplastic-contaminated South Korean shoreline had 50 times more plastic particles in their guts than roaches from a cleaner site, and the contaminated animals also carried elevated levels of brominated flame retardants leached from the polystyrene foam they had ingested. Gene expression analysis revealed that the contaminated roaches showed altered immune, metabolic, and stress-response pathways. Because wharf roaches are a key detritus-consuming species in coastal ecosystems, this study demonstrates that microplastic pollution can have cascading biological effects from the base of the food web.
Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure
Researchers tracked gut microbial enrichment, virome shifts, and metabolomic changes in organisms exposed to polystyrene microplastics, finding Eubacteriales-dominated dysbiosis accompanied by colitis. Microplastic exposure activated polyamine synthesis pathways, altered serotonin and thyroxine metabolism, and increased cholesterol-derived hormone synthesis, revealing complex hormonal and neurochemical disruption.
Unveiling the impact of short-term polyethylene microplastics exposure on metabolomics and gut microbiota in earthworms (Eudrilus euganiae)
Researchers exposed earthworms to polyethylene microplastics and found significant disruptions in their metabolism and gut bacteria, even when no visible signs of stress were present. The microplastics affected energy and lipid metabolism, anti-inflammatory processes, cell signaling, and membrane integrity. The study suggests that microplastics can cause hidden biological harm to soil organisms well before any outward symptoms appear.
Novel functional insights into the microbiome inhabiting marine plastic debris: critical considerations to counteract the challenges of thin biofilms using multi-omics and comparative metaproteomics
Researchers used advanced multi-omics techniques — simultaneously analyzing the DNA, proteins, and metabolic activity of microbes — to study the complex communities of bacteria and other microorganisms that colonize marine plastic debris (the "plastisphere"). The work reveals new ecological functions of these microbial films beyond plastic breakdown, including potential biotechnology applications and risks from pathogen hitchhiking on ocean plastic.
Untargeted metabolomic insights into plastisphere communities in European rivers
Researchers used untargeted metabolomics to characterize plastisphere microbial communities colonizing polyethylene-based plastic pellets in European rivers, simulating microplastic transport between freshwater and marine ecosystems to understand how the plastisphere microbiome and its metabolic outputs shift across environmental transitions.
[Accumulation and Clearance of Polystyrene Microplastics in Brine Shrimp and the Responses of Microbiome and Metabolism].
Researchers exposed brine shrimp (Artemia salina) to polystyrene microplastics of different sizes and concentrations under varying nutritional conditions and analyzed microbiome and metabolic responses. Accumulation and clearance were concentration-dependent, while nutritional status modulated MP uptake; combined microbiome and metabolomics analysis revealed disruptions in microbial community composition and metabolic function.
Toxicological effects of microplastics in Litopenaeus vannamei as indicated by an integrated microbiome, proteomic and metabolomic approach
Shrimp (Litopenaeus vannamei) exposed to five microplastic types for 14 days showed gut microbiota shifts (increased Bacteroidetes and Proteobacteria, decreased Firmicutes) and altered haemolymph proteomes, with each MP type producing distinct immune pathway effects.
Macrogenomes reveal microbial-mediated microplastic degradation pathways in the porcine gut: a hope for solving the environmental challenges of microplastics
A metagenomic study of pig gut contents found a diverse community of microorganisms harboring genes capable of breaking down multiple types of microplastics. This raises the intriguing possibility that gut microbiota in food animals may partially degrade ingested microplastics, but it also raises questions about whether breakdown products or altered microbial communities pose risks that pass up the food chain to humans.
Metabolomic and biochemical disorders reveal the toxicity of environmental microplastics and benzo[a]pyrene in the marine polychaete Hediste diversicolor
This study exposed marine polychaete worms to environmentally realistic concentrations of microplastics and benzo[a]pyrene, a toxic chemical commonly found attached to microplastics. The combination of both pollutants caused more metabolic disruption and biochemical damage than either one alone. Since polychaetes are an important food source for fish, these findings suggest that microplastics carrying toxic chemicals could amplify harm throughout marine food webs.
Nanoplastics induce molecular toxicity in earthworm: Integrated multi-omics, morphological, and intestinal microorganism analyses
Researchers used multi-omics analysis to study how even low concentrations of nanoplastics affect earthworms, important indicators of soil health. They found that nanoplastics accumulated in the earthworms' intestines, damaging their digestive and immune systems and disrupting gut microorganism communities. The study demonstrates that nanoplastics can cause molecular-level harm to soil organisms at concentrations that might be considered environmentally realistic.
Effects of microplastics and phenanthrene on gut microbiome and metabolome alterations in the marine medaka Oryzias melastigma
Researchers exposed marine medaka fish to microplastics combined with phenanthrene, a common organic pollutant, and found that the combination disrupted gut bacteria and metabolism more than either substance alone. Specific gut bacterial communities shifted in response to the combined exposure, leading to changes in important metabolic processes. This study underscores that microplastics in the ocean don't act alone; they interact with other pollutants to amplify harm to aquatic organisms and potentially to the humans who consume seafood.
Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Oryzias javanicus Bleeker, 1854)
Researchers found that polystyrene microplastic exposure altered gut microbiome composition and metabolic profiles in Javanese medaka fish, with effects on amino acid and lipid metabolism pathways suggesting microplastics can disrupt gut health in aquatic organisms.
Unveiling the gut’s plastic predicament: How micro- and nano-plastics drive distinct toxicological pathways in Enchytraeus crypticus
Researchers exposed the soil invertebrate Enchytraeus crypticus to environmentally relevant concentrations of polystyrene microplastics (50 µm) and nanoplastics (100 nm), finding that nanoplastics caused greater gut microenvironment disruption and more severe biotoxicity than microplastics, acting through distinct mechanistic pathways.
Polystyrene-degrading bacteria in the gut microbiome of marine benthic polychaetes support enhanced digestion of plastic fragments
Researchers found that marine worms called clamworms harbor gut bacteria capable of breaking down polystyrene foam, but this digestion also generates microplastics averaging 0.6 mm in diameter, meaning these worms both degrade and produce microplastics — complicating their role in marine plastic pollution.
Interplay Between Superworm and its Gut Microbiome in Facilitating Polyethylene Biodegradation by Host Transcriptomic Analysis: Insights from Xenobiotic Metabolism
Researchers investigated how superworms (Zophobas morio) and their gut microbiome work together to break down polyethylene plastic, identifying key xenobiotic metabolism pathways and host-microbe interactions that drive biodegradation.
Multi-Omics Approach on the Ecotoxicological Assessment of Microplastics
This review examines the application of multi-omics approaches — including genomics, transcriptomics, proteomics, and metabolomics — to the ecotoxicological assessment of microplastics in living organisms. The authors synthesize how these integrated molecular tools are advancing understanding of the mechanistic pathways by which microplastics disrupt biological systems, offering a more comprehensive picture than single-endpoint toxicity studies.