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20 resultsShowing papers similar to Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty
ClearMammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
This review summarized how mTOR signaling regulates skeletal muscle maintenance and how dysregulation contributes to sarcopenia, the age-related loss of muscle mass and function. Intervention strategies targeting mTOR including exercise, caloric restriction, and plant extract supplementation show promise for slowing muscle decline in aging.
A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia
This review explores natural dietary ingredients, including plant extracts, phytochemicals, and probiotics, that may help prevent or manage sarcopenia, the age-related loss of muscle mass and strength. Researchers found that certain compounds can influence muscle protein synthesis, reduce inflammation, and support gut health in ways that benefit muscle maintenance. The study highlights how diet-based approaches could complement exercise in preserving muscle function as people age.
Nrf2-dependent redox regulation protects myoblasts from polystyrene nanoplastic-induced premature senescence
Researchers showed that polystyrene nanoplastics trigger premature senescence (accelerated aging) in mouse muscle precursor cells by downregulating the antioxidant regulator Nrf2, and that activating Nrf2 with sulforaphane — a compound found in broccoli — significantly protected cells by restoring mitochondrial integrity and reducing oxidative stress markers.
Exposure to polystyrene nanoplastics promotes premature cellular senescence through mitochondrial ROS production and dysfunction in pre-differentiated skeletal myoblasts
This lab study found that polystyrene nanoplastics caused premature aging in muscle precursor cells by damaging their mitochondria and triggering excessive production of harmful molecules called reactive oxygen species. The nanoplastics were absorbed into cells, accumulated there, and caused the cells to stop dividing and show signs of aging. This suggests that nanoplastic exposure could contribute to muscle deterioration and aging-related conditions by damaging the cells responsible for muscle repair.
The role of ageing and oxidative stress in intervertebral disc degeneration
This review details how aging and oxidative stress synergistically drive intervertebral disc degeneration through mitochondrial dysfunction, increased reactive oxygen species, and decreased antioxidant capacity. The progressive breakdown of disc matrix components under chronic oxidative damage suggests antioxidant therapies could potentially slow disc degeneration.
Resveratrol attenuated high intensity exercise training-induced inflammation and ferroptosis via Nrf2/FTH1/GPX4 pathway in intestine of mice
Researchers found that resveratrol attenuated inflammation and ferroptosis caused by high-intensity exercise training in the intestines of mice. The protective effect was mediated through activation of the Nrf2/FTH1/GPX4 pathway in colon tissue, suggesting potential applications for preventing exercise-induced gut damage.
Microplastics induce insulin resistance by causing mitochondrial dysfunction associated with mROS in skeletal muscle in vitro
Researchers exposed human muscle cells to polystyrene micro and nanoplastics and found that the particles caused insulin resistance, meaning the cells could not properly absorb sugar from the blood. The plastics damaged the cells' mitochondria (the energy-producing structures) and triggered harmful oxidative stress, but a mitochondria-protecting antioxidant reversed the damage. This study suggests that microplastic exposure could contribute to metabolic problems like type 2 diabetes by impairing how muscles process sugar.
Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats
Researchers found that ischemic stroke in rats caused significant skeletal muscle damage and altered the muscle transcriptome profile, providing insights into post-stroke muscle pathology and potential targets for rehabilitation interventions.
Exposome on skeletal muscle system: a mini-review
This mini-review examines how environmental exposures, including microplastics, heavy metals, and other pollutants, affect skeletal muscle biology. Evidence indicates that microplastics may delay muscle regeneration and promote fat cell formation through specific signaling pathways, suggesting that cumulative environmental exposures could have meaningful effects on muscle health across the lifespan.
Role of TRPC6 in apoptosis of skeletal muscle ischemia/reperfusion injury
This study used TRPC6 knockout mice and hypoxia/reoxygenation cell models to show that TRPC6 is a key ion channel in skeletal muscle ischemia-reperfusion injury, with its deletion reducing calcium overload, decreasing apoptosis, and partially restoring exercise capacity.
Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia
Researchers found that the anti-aging protein Klotho is reduced in preeclampsia — a dangerous pregnancy condition — and that restoring Klotho levels protected placental cells from oxygen deprivation-induced damage by activating the Nrf2 antioxidant pathway, pointing to Klotho as both a diagnostic marker and potential treatment target.
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Researchers reviewed how mitochondria — the cell's energy factories — communicate both within and between cells, and how this communication breaks down as we age. When mitochondrial function and signaling both fail together, it creates a damaging cycle that drives age-related diseases, but targeting these pathways may offer new ways to extend healthy lifespan.
Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies
This review explores how the Nrf2 signaling pathway, a key defense system against oxidative stress, plays a role in ovarian aging, which leads to menopause, reduced fertility, and health risks like osteoporosis. While not focused on microplastics specifically, the Nrf2 pathway is one of the main systems that microplastics disrupt when they accumulate in reproductive tissues. Understanding this pathway helps explain how environmental pollutants like microplastics could accelerate ovarian aging and harm fertility.
Microplastics/nanoplastics contribute to aging and age-related diseases: Mitochondrial dysfunction as a crucial role
This review examines how microplastics and nanoplastics may contribute to aging and age-related conditions by damaging mitochondria, the energy-producing structures inside cells. Researchers describe how these tiny plastic particles enter the body through food, water, and air, and accumulate in various organs where they can disrupt normal mitochondrial function. The study suggests that microplastic-driven mitochondrial damage could be an underappreciated factor in the aging process and related health decline.
Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy
This review examines how redox regulation of immunometabolism in retinal microglia contributes to diabetic retinopathy progression. The study discusses how microglial activation involves tightly regulated metabolic reprogramming, and explores potential therapeutic targets within redox signaling pathways.
Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases
This systematic review found that intermittent fasting shows promise as an anti-aging strategy through its effects on cellular and molecular mechanisms, including improved autophagy, reduced oxidative stress, and enhanced metabolic function. The evidence suggests intermittent fasting may help prevent age-associated diseases like cardiovascular disease, diabetes, and neurodegenerative disorders.
Nexus Between Sarcopenia and Microbiome Research: A Bibliometric Exploration
Researchers conducted a bibliometric analysis of the intersection between sarcopenia and microbiome research, analyzing 997 articles from the Science Citation Index Extended Database to map scientific production, international collaboration networks, and emerging research hotspots in this growing field.
Microplastics and exercise: impacts on performance and physiological health
This review examines how microplastic exposure may affect athletic performance and physiological health, discussing evidence that MPs can enter the body through exercise-related inhalation and ingestion and may impair respiratory function, endocrine signaling, and inflammation pathways relevant to sports performance.
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity
Researchers reviewed evidence on micro- and nanoplastic exposure across the human lifespan through a One Health lens, finding that MNPs trigger oxidative stress, inflammation, mitochondrial dysfunction, and cellular senescence—mechanisms central to aging—and that older adults face compounded risk from lifetime accumulation and diminished physiological resilience, though direct epidemiological data in this population remain sparse.
N-acetylcysteine suppresses proteasome pathway activation and muscular damage induced by microplastics and chromium nanoparticles
Researchers found chromium nanoparticles and microplastics co-accumulating in human peri-implant muscle tissue from orthopedic patients, and showed in vitro that their combined exposure elevated reactive oxygen species and pro-inflammatory markers, while the antioxidant N-acetylcysteine suppressed the proteasome pathway activation and muscle damage.