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Papers
61,005 resultsShowing papers similar to Chitosan-Polycaprolactone Core-Shell Microparticles for Sustained Delivery of Bevacizumab.
ClearBiodegradable Nanoplastic: a Tool for Drug Delivery and Environmental Challenge
This review discusses the dual nature of biodegradable nanoplastics — their promise as targeted drug delivery vehicles due to their controllable surface chemistry, versus the environmental concern of uncontrolled nanoplastic accumulation from biodegradable polymer degradation in ecosystems.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery
This review examines how nanoparticles made from chitosan and alginate (natural sugar-based materials) can deliver antibacterial drugs more effectively by improving how the drugs dissolve and how long they stay active. While not directly about microplastics, these biodegradable nanoparticle systems could offer alternatives to plastic-based drug delivery methods, reducing reliance on synthetic plastics in medicine.
Pharmacokinetic Profile of Intra-articular Fluticasone Propionate Microparticles in Beagle Dog Knees.
This pharmacokinetics study tracked the distribution of a slow-release corticosteroid microparticle formulation injected into dog knee joints, finding that drug concentration peaked rapidly in synovial fluid. This paper uses 'microparticles' in a pharmaceutical drug delivery context and is not related to environmental plastic pollution.
Integrating Artificial Intelligence with Quality by Design in the Formulation of Lecithin/Chitosan Nanoparticles of a Poorly Water-Soluble Drug
This study used artificial intelligence and quality-by-design methods to create optimized nanoparticles for delivering a cancer-fighting drug called silymarin. While not directly about microplastics, the research advances understanding of how nanoparticles interact with biological systems, which is relevant because nanoplastics behave similarly in the body. The techniques developed here could help researchers better predict how nanoscale plastic particles are absorbed and distributed in human tissues.
Preparation and Characterization of Cellulose/Silk Fibroin Composites Microparticles for Drug Controlled-Release Applications
This paper is not about microplastics; it focuses on developing cellulose and silk fibroin composite microparticles as controlled drug delivery systems, with no relevance to plastic pollution or environmental health.
Shaping, Degradation And Drug Release Of Biosourced Particles Made From Acrylated Vegetable Oils
Researchers developed biodegradable particles from acrylated vegetable oils as a sustainable alternative to petroleum-based polymers, characterizing their shaping, degradation kinetics, and drug release profiles. The biosourced particles demonstrated controlled degradation and tunable drug release, offering a pathway to reduce microplastic pollution from biomedical and pharmaceutical applications.
Surface Morphology-Enhanced Delivery of Bioinspired Eco-Friendly Microcapsules
Researchers developed biodegradable microcapsules made from proteins and biominerals as a sustainable replacement for the synthetic polymer microplastic particles used in many consumer products including cosmetics and paints. The capsules degraded naturally and performed comparably to conventional capsules in controlled release tests. Replacing non-biodegradable microcapsules with protein-mineral alternatives could significantly reduce microplastic pollution from consumer goods.
Effect of paclitaxel octreotide conjugate on human ovarian paclitaxel-resistant cell xenograft tumor model and the mechanism underlying reversal of paclitaxel resistance
This paper is not relevant to microplastics — it examines the efficacy of a paclitaxel-octreotide conjugate for overcoming drug resistance in human ovarian cancer cell xenograft models.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle.
This study tested polymer microparticles as a delivery system for a cancer drug in brain tumor models. This is a drug delivery and cancer treatment research paper with no direct connection to environmental microplastics.
Polyethylene Glycol-Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery
This paper is not about microplastics — it reviews the design and synthesis of polyethylene glycol (PEG)-based polymer-drug conjugates as targeted drug delivery systems for cancer and other diseases, with no relevance to microplastic pollution or environmental health.
Impact of Microplastic Contaminants on Drug Stability and Safety
Researchers reviewed how microplastic contaminants may alter the stability, bioavailability, and safety of pharmaceutical products by adsorbing drug compounds and releasing them unpredictably. Survey data from pharmaceutical quality assurance professionals and literature synthesis identified specific mechanisms by which MPs could degrade drug formulations, flagging an underexplored drug safety concern.
End group chemistry modulates physical properties and biomolecule release from biodegradable polyesters.
Researchers developed models of end group chemistry in biodegradable poly(lactic-co-glycolic acid) (PLGA) microparticles to better predict protein release kinetics, finding that end group composition modulates both the physical properties and biomolecule release profiles of these drug delivery systems.
Hierarchical Plant Protein Microcapsules for Hydrophilic and Hydrophobic Cargo Molecules
Not relevant to microplastics — this paper describes biodegradable plant protein microcapsules for food and pharmaceutical delivery, which meet ISO biodegradability standards for freshwater but are not themselves a microplastic source or subject.
Keratin–Chitosan Microcapsules via Membrane Emulsification and Interfacial Complexation
This study developed a continuous-production method for making biodegradable microcapsules from keratin and chitosan — proteins and natural polymers — capable of producing millions of capsules per minute. Biodegradable capsule materials offer an alternative to the synthetic microplastic spheres currently used in cosmetics and other controlled-release applications.
Spray-Dried Chitosan Hydrogel Particles as a Potential Delivery System for Benzydamine Hydrochloride
Researchers developed spray-dried chitosan hydrogel microparticles as potential drug delivery systems for benzydamine hydrochloride. The study explored different formulation approaches using crosslinking and coating techniques, contributing to biodegradable polymer research that offers alternatives to conventional plastic-based pharmaceutical delivery materials.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Synthesis of model polyethylene particles for the study of nanoplastics in the oceans
Researchers developed a synthesis method for model polyethylene particles designed to replicate the physicochemical properties of naturally degraded nanoplastics in the ocean, addressing the need for environmentally representative reference materials for studying nanoplastic behavior in marine systems.
Triple-Emulsion-Based Antibubbles: A Step Forward in Fabricating Novel Multi-Drug Delivery Systems
Not relevant to microplastics — this paper describes a novel triple-emulsion 'antibubble' drug delivery system designed to carry both water-soluble and fat-soluble medications simultaneously.
Biodegradable chito-beads replacing non-biodegradable microplastics for cosmetics
Biodegradable microbeads were prepared by reacetylation of chitosan as a direct substitute for synthetic polymer microbeads in cosmetic exfoliators. The chitosan-based beads demonstrated suitable mechanical properties and high cleansing efficiency, offering a viable biodegradable alternative to conventional microplastic microbeads.
Unveiling nanoplastic release from single-use eyedrop vials: A particle-based approach for identification and quantification
Researchers used advanced analytical techniques to detect and quantify nanoplastics released from single-use disposable eyedrop containers. They found that thousands of micro- and nanoplastic particles were released simply upon opening the containers, with 88% of particles falling in the nanoscale range. The findings raise concerns about direct ocular exposure to nanoplastics from a common medical product.
Degradable poly(β-amino ester) microparticles for cleansing products and food fortification
Researchers developed degradable microparticles made from a material that breaks down into sugar and amino acid byproducts, designed to replace the non-degradable plastic microbeads used in cleansing products and food fortification. These new particles performed similarly to conventional plastic microbeads but dissolve harmlessly in the environment. This innovation could help reduce one significant source of microplastic pollution that enters waterways and the food supply.
Evaluation of the Antimicrobial Activity of Chitosan Nanoparticles against Listeria monocytogenes
Not relevant to microplastics — this is a microbiology study testing the antimicrobial effectiveness of chitosan nanoparticles from different sources against the foodborne pathogen Listeria monocytogenes, finding that nanoparticle size — not just molecular weight or deacetylation degree — drives efficacy.