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61,005 resultsShowing papers similar to A Multisystemic Approach Revealed Aminated Polystyrene Nanoparticles-Induced Neurotoxicity.
ClearNeuronal damage induced by nanopolystyrene particles in nematodeCaenorhabditis elegans
C. elegans nematodes were chronically exposed to nanopolystyrene particles and found to develop neuronal damage affecting both development and function of the nervous system after long-term exposure at environmentally relevant concentrations. The study provides early evidence that nanoplastics can cause neurological harm in an animal model, raising questions about potential neurotoxicity in other species.
Are all nanoplastics equally neurotoxic? Influence of size and surface functionalization on the toxicity of polystyrene nanoplastics in human neuronal cells
Researchers tested four types of polystyrene nanoplastics on human neuronal cells and found that toxicity varied dramatically depending on particle surface chemistry. Particles with amine surface groups were the most harmful, significantly reducing cell survival and causing visible damage to cell structures, while unmodified particles showed minimal toxicity, suggesting that surface properties matter as much as size when assessing nanoplastic risks.
Role of nanoparticle surface charge in their toxicity
This study examined how surface charge (carboxyl vs. amino functionalization) affects the toxicity of polystyrene nanoparticles formed during plastic degradation, noting that nanoparticle toxicity can differ substantially from bulk material. Results highlighted that surface chemistry is a critical determinant of nanoparticle behavior in biological environments.
What Is on the Outside Matters—Surface Charge and Dissolve Organic Matter Association Affect the Toxicity and Physiological Mode of Action of Polystyrene Nanoplastics toC. elegans
Researchers investigated how surface charge and organic matter coatings affect the toxicity of polystyrene nanoplastics to the nematode C. elegans. Positively charged nanoplastics were over 60 times more toxic than negatively charged ones, and organic matter coatings reduced toxicity across all particle types. The findings suggest that surface chemistry plays a critical role in nanoplastic toxicity and should be considered when assessing environmental risks.
Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain
Researchers exposed three types of primary mouse brain cells to 100 nm polystyrene nanoplastics and found that neurons underwent apoptosis while astrocytes survived but developed reactive astrocytosis with elevated inflammatory markers, suggesting that neuronal vulnerability to nanoplastic accumulation may be amplified by astrocyte-driven neuroinflammation.
Impact of polystyrene nanoplastics on early life stages of marine invertebrates: current knowledge and future research perspectives
This review synthesizes knowledge on how polystyrene nanoparticles affect the early life stages of marine invertebrates across five phyla, finding that toxicity depends heavily on surface charge, with amino-modified particles being most harmful to embryos and larvae.
Charge-specific adverse effects of polystyrene nanoplastics on zebrafish (Danio rerio) development and behavior
Researchers exposed developing zebrafish to positively and negatively charged nanoplastics and found that the positively charged particles were significantly more toxic, accumulating in the brain and gut and causing developmental delays and brain cell death. The two types of nanoplastics affected different neurotransmitter pathways and interacted with different brain receptors, explaining their distinct behavioral effects. The study demonstrates that the surface charge of nanoplastics plays a critical role in determining their toxicity to developing organisms.
Neurophysiological and Behavioral Effects of Micro- and Nanoplastics in Aquatic Organisms
Researchers reviewed evidence that micro- and nanoplastics in aquatic environments cross the blood-brain barrier, accumulate in neural tissues, and cause oxidative stress, neuroinflammation, and disrupted neurotransmitter signaling, with downstream effects on locomotion, feeding, predator avoidance, and social behavior across multiple aquatic species.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish
Scientists discovered that smaller nanoplastics cause more severe brain and nerve damage in zebrafish than larger ones, and identified the molecular pathways behind this size-dependent toxicity. The smaller particles more easily crossed biological barriers and triggered greater oxidative stress and inflammation in the nervous system, which is important for understanding potential neurological risks of nanoplastic exposure.
Molecular effects of polystyrene nanoplastics on human neural stem cells
Researchers exposed human brain stem cells to tiny polystyrene nanoplastics and found they caused oxidative stress, DNA damage, inflammation, and cell death. These findings suggest that nanoplastics could potentially harm brain development if they reach neural tissue, though more research is needed to understand real-world exposure levels.
Polystyrene (nano)microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects inCaenorhabditis elegans
Researchers found that polystyrene micro- and nanoplastics cause neurotoxicity and oxidative damage in the model organism C. elegans, with effects varying by particle size. Smaller nanoscale particles tended to cause more severe toxic responses than larger microplastic particles. The study highlights that the size of plastic particles is an important factor in determining how harmful they are to living organisms.
Cytotoxicity of amine-modified polystyrene MPs and NPs on neural stem cells cultured from mouse subventricular zone
Researchers tested the effects of polystyrene microplastics and nanoplastics with a positive surface charge on neural stem cells from mouse brains. Both sizes of particles reduced cell survival, but nanoplastics were significantly more toxic at lower concentrations, causing cell death and preventing stem cells from developing into mature brain cells. These findings suggest that nanoplastics that reach the brain could potentially harm the nervous system's ability to repair and maintain itself.
[Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation].
Researchers found that gestational exposure to polystyrene nanoplastics in rats caused dose-dependent reductions in fetal body weight, body length, and brain development, with smaller 25 nm particles producing more pronounced neurotoxic effects than 50 nm particles.
Neurotoxicityof Micro- and Nanoplastics: A ComprehensiveReview of Central Nervous System Impacts
This comprehensive review examines neurotoxicity of micro- and nanoplastics, synthesizing evidence that MNP exposure disrupts neural signaling, promotes neuroinflammation, crosses the blood-brain barrier, and may contribute to neurodegenerative and neurodevelopmental disorders.
The plastic brain part II: new insights into micro- and nanoplastics neurotoxicity
This systematic review evaluated neurotoxicity evidence from studies on micro- and nanoplastic (MNP) exposure, covering a rapidly growing body of literature. The authors found consistent evidence of neuroinflammation, oxidative stress, and behavioral disruption across multiple model systems, though dose-response relationships and human relevance remain areas of uncertainty.
Effects of Polystyrene Nanoplastics on the Biology of Human Neural Stem Cells and Human Cerebral Organoids.
This study investigated the effects of polystyrene nanoplastics on human neural stem cells and human cerebral organoids, examining whether nanoplastics that have been shown to cross the blood-brain barrier and placenta can disrupt normal brain development. Given the lack of prior research on nanoplastic effects on the developing brain, the findings carry significant implications for understanding neurodevelopmental risks from early-life plastic exposure.
Exposure to nanopolystyrene and its 4 chemically modified derivatives at predicted environmental concentrations causes differently regulatory mechanisms in nematode Caenorhabditis elegans
Researchers found that nanopolystyrene and four chemically modified derivatives caused distinct toxicity patterns in C. elegans nematodes at environmentally predicted concentrations, with surface chemistry significantly influencing the regulatory mechanisms affected.
Primary astrocytes as a cellular depot of polystyrene nanoparticles
Researchers found that astrocytes — support cells in the brain — absorb polystyrene nanoplastics far more efficiently than neurons and act as a cellular buffer to protect nerve cells, but become overactivated when the particle load is too high, losing their protective function and potentially contributing to neurological harm.
Cerebral to SystemicRepresentations of Alzheimer’sPathogenesis Stimulated by Polystyrene Nanoplastics
Researchers exposed both wild-type and APP/PS1 Alzheimer's model mice to environmental levels of polystyrene nanoplastics and measured Alzheimer's-like pathology progression. Nanoplastics exacerbated cognitive decline, microglial activation, and hippocampal neuronal death, particularly in the Alzheimer's model, with systemic inflammatory effects suggesting plastic particles may accelerate neurodegeneration.
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans
Researchers used the nematode C. elegans as a model to study how carboxyl-modified polystyrene microplastics affect the nervous system. They found that even at low concentrations, these modified microplastics caused more severe neurotoxicity than unmodified polystyrene, disrupting dopamine, glutamate, serotonin, and GABA neurotransmission. The study suggests that surface modifications on microplastics may significantly increase their potential to cause neurological harm.
Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure
Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.
Lifelong exposure to polystyrene-nanoplastics induces an attention-deficit hyperactivity disorder-like phenotype and impairs brain aging in mice
Mice exposed to nanoplastics throughout their entire lives -- from the womb through old age -- developed ADHD-like symptoms as adults, including hyperactivity, risk-taking behavior, and impaired learning, and showed a lower seizure threshold in old age. These behavioral changes were accompanied by altered brain proteins and accelerated brain aging at the cellular level, suggesting lifelong nanoplastic exposure may contribute to neurodevelopmental and neurodegenerative disorders.
Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice
Researchers exposed male Swiss mice to polystyrene nanoplastics at two doses over 20 days and assessed behavioral, neurological, and genetic effects. The study found that nanoplastic exposure induced anxiolytic-like behavior, altered antipredator defensive responses, and caused DNA damage in erythrocytes, suggesting that nanoplastics can affect mammalian brain function and genomic integrity.