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Papers
61,005 resultsShowing papers similar to DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species
ClearInsect Insights at the Single-Cell Level: Technologies and Applications
This paper is not about microplastics; it reviews single-cell RNA sequencing technologies and their applications in insect biology research.
Effective multi-modal clustering method via skip aggregation network for parallel scRNA-seq and scATAC-seq data
This paper presents a new computational method for analyzing single-cell genomic data by clustering cells based on both their gene expression and chromatin accessibility patterns. The technique uses a skip aggregation network to better integrate information from multiple data types. While not related to microplastics, this type of advanced analytical tool could potentially be applied to study how microplastic exposure affects gene expression at the single-cell level in human tissues.
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
This review summarizes research using fruit flies as a model to study how micro- and nanoplastics harm living organisms. Studies show these tiny plastic particles cause oxidative stress, inflammation, DNA damage, and reproductive problems in flies, with males being more vulnerable than females -- findings that may help us understand similar risks in humans.
Data mining of molecular data resulting from environmental exposure to xenobiotics
Researchers characterized the multi-layer gene expression response of human airway and liver cells exposed to polystyrene microplastics across multiple doses and time points. They found thousands of differentially expressed genes along with extensive reprogramming of gene isoforms, affecting protein coding capacity and RNA stability. The study demonstrates that microplastic exposure triggers a structured, dose- and time-dependent remodeling of cellular gene expression programs in human tissue models.
The Impact of Microplastics on Tissue-specific Gene Expression in the Tropical House Cricket, G. sigillatus
Researchers examined tissue-specific gene expression responses in tropical house crickets (Gryllodes sigillatus) fed microplastics, using RNA sequencing across midgut, hindgut, fat body, and ovary tissues to reveal impacts on immune function and mitochondrial activity.
A single-cell atlas of the single versus multiple parous Hu Sheep ovary
This is a sheep reproductive biology study using single-cell RNA sequencing to investigate differences in ovarian gene expression between high- and low-fertility ewes; it is not a microplastics research paper.
The effects of microplastics and nanoplastics upon history, policies, and Drosophila melanogaster
This study examined the effects of microplastics and nanoplastics on the fruit fly Drosophila melanogaster, finding that dietary exposure to these pervasive environmental contaminants causes measurable biological harm and making the case for stronger regulatory policies.
A guided tour in protein interaction space: Coiled coils from the yeast proteome
The abstract for this entry describes growing global concerns about micro- and nanoplastics and the need for better analytical methods to detect and characterize them. The title refers to a protein interaction study in yeast, indicating a database mismatch.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Food nutrition and toxicology targeting on specific organs in the era ofsingle-cell sequencing
This review examines how single-cell sequencing technologies can reveal organ-specific effects of food nutrients and toxicants, including contaminants like microplastics, by uncovering cellular heterogeneity and tissue-biased responses that traditional methods miss.
SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data
Researchers developed SGCRNA, a new computational tool for analyzing gene co-expression networks that addresses limitations of the widely used WGCNA method. The tool removes the assumption of scale-free topology, eliminates manual parameter tuning, and accounts for regression line slopes. While not specific to microplastics research, this bioinformatics tool can be applied to analyze multi-omic datasets from studies examining biological responses to environmental contaminants.
Multidimensional analysis methods for flow cytometry : Pushing the boundaries
This thesis developed new methods for analyzing multidimensional flow cytometry data to better identify cell populations. While a bioinformatics and immunology paper, flow cytometry is also used in cutting-edge research to detect and quantify micro- and nanoplastics in biological fluids.
Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines
Researchers used single-cell RNA sequencing to examine how different sizes of polystyrene microplastics affect intestinal cell populations in zebrafish. The study revealed size-dependent effects on immune and secretory cell populations, providing a detailed transcriptomic view of how microplastics disrupt intestinal function at the individual cell level and alter the interplay between intestinal cells and gut microbiota.
The impact of microplastics on tissue-specific gene expression in the tropical house cricket, Gryllodes sigillatus
Researchers fed microplastics to tropical house crickets and measured gene expression changes across four different tissue types. They found that microplastic consumption triggered unique responses in each tissue, with notable changes in genes related to stress, immunity, metabolism, and even cancer pathways. The study demonstrates that microplastic exposure affects different organs in distinct ways, highlighting the complexity of how plastic pollution impacts living organisms.
Polypropylene microplastics affect the physiology in Drosophila model
Researchers found that polypropylene microplastics negatively affected the physiology of Drosophila fruit flies, complementing earlier work on polyethylene terephthalate microplastics and demonstrating that different polymer types can impair organism health.
In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain
This paper is not relevant to microplastics research — it evaluates the neurogenotoxic effects of the fungicide validamycin A in an in vivo vertebrate model, examining DNA damage in brain cells.
Single-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics
Researchers used single-cell gene analysis to examine how polystyrene nanoplastics affect different cell types in zebrafish livers. They discovered that various liver cell populations responded to nanoplastic exposure in distinctly different ways, with some cell types showing more disruption to fat metabolism and stress response genes than others. The study reveals that nanoplastic toxicity in the liver is not uniform and that certain cell populations may be more vulnerable than previously understood.
Neuromuscular, retinal, and reproductive impact of low-dose polystyrene microplastics on Drosophila
Researchers found that even low doses of polystyrene microplastics impaired neuromuscular signaling, altered retinal function, and reduced reproductive rates in fruit flies, with gene expression changes in key signaling pathways underlying these effects.
Effects of PET microplastics on the physiology of Drosophila
Researchers used Drosophila fruit flies as a model to study the physiological effects of PET microplastics, finding that ingestion affected reproduction, lifespan, and gut function. The study suggests that even common plastic types found in food packaging can have measurable biological effects when consumed by living organisms.
The heart of plastic: utilizing the Drosophila model to investigate the effects of micro/nanoplastics on heart function
Researchers used fruit flies as a model to study how micro- and nanoplastics affect heart function, an area with very limited research despite the known presence of plastics in human cardiovascular tissue. They reviewed existing evidence showing that plastic particles can alter heart rate, trigger stress responses, and accumulate in cardiac tissue. The study highlights the fruit fly as a fast, affordable model for investigating the potential cardiovascular risks of plastic pollution.
High-concentration polyethylene and polystyrene microplastics co-exposure shorten insect lifespan and impose ecological risk: Multi-omics evidence from Drosophila melanogaster
Researchers used fruit flies as a model organism to study how co-exposure to high concentrations of polyethylene and polystyrene microplastics affects insect lifespan. Multi-omics analysis revealed that microplastic co-exposure significantly shortened lifespan and disrupted key biological pathways, suggesting potential ecological risks from cumulative microplastic exposure in the environment.
Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review
This systematic review examines how zebrafish and fruit flies are being used as model organisms to study the effects of micro- and nanoplastics on living systems. These animal models help researchers understand how plastic particles interact with biological tissues, providing insights that are relevant to potential human health effects.
Transcriptome Profiling of Developing Testes and Spermatogenesis in the Qianbei Ma Goat
This paper is not relevant to microplastics research — it uses RNA sequencing to profile gene expression changes during testis development and spermatogenesis in Qianbei Ma goats at different stages of maturity.
Suborganismal responses of the aquatic midge Chironomus riparius to polyethylene microplastics
Researchers exposed Chironomus riparius larvae to polyethylene microplastics and used transcriptomics and metabolomics to characterize suborganismal responses, finding disruption of oxidative stress pathways, energy metabolism, and cuticle synthesis — effects not captured by standard life-history endpoints alone.