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61,006 resultsShowing papers similar to GenX-loaded polystyrene microplastics exacerbate intestinal injury in mice via barrier impairment and microbial dysregulation
ClearImpact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging
Researchers found that polystyrene microplastic exposure worsened intestinal barrier dysfunction in mice on high-fat diets, with the combination of obesity and microplastic exposure producing greater gut permeability and inflammation than either factor alone, suggesting compounding risks in metabolically vulnerable individuals.