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Papers
20 resultsShowing papers similar to Author response: Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
ClearEnvironmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
Researchers used STED nanoscopy to reveal that environmental enrichment enhances the patterning and remodeling of synaptic nanoarchitecture in the brain, demonstrating experience-dependent structural plasticity at an unprecedented nanoscale resolution.
Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture revealed by STED nanoscopy
This neuroscience study used STED super-resolution microscopy to show that environmental enrichment enhances the size and structural complexity of synapses in the brain. It is a basic neuroscience paper not related to microplastics or environmental plastic pollution.
Editor's evaluation: Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
This is an editorial evaluation of a neuroscience study on how environmental enrichment changes the physical structure of synaptic connections in the brain. It is not related to microplastics or environmental pollution.
Decision letter: Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy
This is a decision letter from peer reviewers evaluating a neuroscience paper on synaptic plasticity and environmental enrichment. It is not related to microplastics or environmental contamination.
Imaging dendritic spines in the hippocampus of a living mouse by 3D-STED microscopy
Researchers extended 3D STED super-resolution microscopy to image dendritic spines in the hippocampus of living mice, achieving nanoscale resolution in three dimensions within deep brain tissue and opening new possibilities for studying synaptic structures in vivo.
Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity
Researchers used chronic in vivo STED nanoscopy to track dendritic spine geometry in mouse neocortex over one month, finding that spine heads and necks undergo extensive, largely uncorrelated remodeling even without induced plasticity. The results indicate that multiple independent mechanisms drive spine structural dynamics beyond LTP-dependent pathways.
In vivo super-resolution of the brain – How to visualize the hidden nanoplasticity?
Researchers reviewed how super-resolution fluorescence microscopy techniques — which allow scientists to image structures smaller than what conventional light microscopes can resolve — are being used to study the nanoscale structure and plasticity of brain synapses in living mice. These imaging advances help reveal how tiny changes in brain connections relate to learning and memory, using "nanoplasticity" in its neurological sense rather than as a reference to plastic pollution.
Imaging dendritic spines in the hippocampus of a living mouse by 3D-stimulated emission depletion microscopy
This paper is not about microplastics; it presents an in vivo 3D super-resolution microscopy methodology for imaging dendritic spines in the mouse hippocampus.
Cortex-Wide, Cellular-Resolution Volumetric Imaging with a Modular Two-Photon Imaging Platform
This paper presents Meso2P, a new two-photon microscope capable of imaging the entire mouse cortex at single-cell resolution — a significant advance in neuroscience instrumentation. Among its demonstrated applications is the ability to track the distribution of micro- and nanoplastic particles in living brain tissue in real time. While primarily a neuroscience tool, its capacity to visualize nanoplastics in the brain non-invasively could become valuable for directly studying how plastic particles move through and accumulate in neural tissue.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence, second harmonic generation, and coherent Raman scattering microscopy in a single instrument to image micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics crossed the blood-brain barrier and accumulated in lipid-rich brain regions in mouse models.
Editorial: 15 years of Frontiers in Cellular Neuroscience: super-resolution microscopy in the healthy and the injured brain
This editorial introduces a research collection on super-resolution microscopy techniques applied to the healthy and injured brain, highlighting how methods that surpass the diffraction limit of classical fluorescence microscopy are revealing new insights into synaptic organization and cellular pathology. The collection covers advances in both imaging hardware and computational image analysis relevant to neuroscience research.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence microscopy, second harmonic generation imaging, and coherent Raman scattering to detect and map micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics were found to cross the blood-brain barrier and accumulate in lipid-rich brain regions in animal models.
Single-Particle Resolution Fluorescence Microscopy of Nanoplastics
Researchers developed a super-resolution fluorescence microscopy technique that enables single-particle detection and precise localization of nanoplastics in biological tissues and environmental samples. This advancement addresses a major limitation in nanoplastic research, as conventional microscopy lacks the resolution to distinguish individual nanoplastics from background fluorescence or free dye.
Visualization of labeled micro- and nanoplastics in interaction with algae, using super-resolution stimulated emission depletion microscopy and fluorescence lifetime imaging
A labeling and STED super-resolution microscopy method was developed to visualize non-fluorescent micro- and nanoplastics of various polymers, shapes, and sizes in interaction with autofluorescent marine microalgae, overcoming a key challenge in distinguishing nanoplastics from biological material.
Fluorescence radial fluctuation enables two-photon super-resolution microscopy
Researchers applied super-resolution radial fluctuation analysis to two-photon microscopy to achieve high-resolution imaging deep within brain tissue. The technique achieved spatial resolution comparable to structured illumination microscopy at depths of several hundred micrometers and enabled the first in vivo super-resolution imaging of the fifth layer of the cerebral cortex, offering an accessible upgrade for existing two-photon microscope systems.
Prenatal exposure on nanoplastics: A study of spatial transcriptomics in hippocampal offspring
Using advanced spatial gene-mapping technology, researchers found that prenatal exposure to nanoplastics caused significant changes in gene activity throughout the hippocampus, the brain region responsible for learning and memory, in rat offspring. The nanoplastics altered the expression of genes involved in brain cell communication, energy production, and development. This study provides detailed evidence that nanoplastic exposure during pregnancy could disrupt brain development in ways that may affect cognitive function.
The Effects of Nanoplastics on the Dopamine System of Cerebrocortical Neurons
Researchers studied how nanoplastics affect the dopamine system in brain neurons grown in the lab. They found that nanoplastics accumulated inside neurons in a dose-dependent manner and altered the levels of proteins involved in dopamine signaling. These results suggest that nanoplastic exposure could potentially interfere with brain chemistry, though more research is needed to understand what this means for human health.
Direct Quantification of Nanoplastics Neurotoxicity by Single‐Vesicle Electrochemistry
Using single-vesicle electrochemistry, this study provides the first direct measurement of how nanoplastics disrupt neurotransmitter release at the level of individual nerve cells. Polystyrene nanoplastics taken up by neurons disrupted the cellular machinery controlling how vesicles fuse and release catecholamines (like dopamine and norepinephrine), reducing both the amount of neurotransmitter released and the frequency of release events. These findings are concerning because they suggest nanoplastic exposure could interfere with normal brain signaling at concentrations that don't immediately kill cells.
Fast detection and 3D imaging of nanoplastics and microplastics by stimulated Raman scattering microscopy
Researchers developed a fast imaging technique using stimulated Raman scattering microscopy to detect and create 3D maps of nanoplastics and microplastics at the single-particle level. The method can identify plastic particles as small as 100 nanometers and distinguish between different polymer types without the need for dyes or labels. This technology could help scientists more accurately track tiny plastic particles in environmental and biological samples.
Accumulation of nanoplastics in human cells as visualized and quantified by hyperspectral imaging with enhanced dark-field microscopy
Researchers developed a label-free imaging technique to visualize and count nanoplastic particles that accumulate inside human cells, using enhanced dark-field microscopy combined with hyperspectral imaging. The method successfully tracked polystyrene nanoplastics entering cells over time and measured accumulation rates without needing fluorescent labels. This tool could improve the accuracy of future studies assessing how nanoplastics build up in human tissue and what concentration levels may pose health risks.