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61,005 resultsShowing papers similar to Effect of Early-Life Exposure of Polystyrene Microplastics on Behavior and DNA Methylation in Later Life Stage of Zebrafish
ClearEffect of Early Life Exposure of Polystyrene Microplastics on Behavior and DNA Methylation in Later Life Stage of Zebrafish
Zebrafish were exposed to polystyrene microplastics early in life, and researchers tracked behavioral changes and DNA methylation patterns in adulthood. Early microplastic exposure led to anxiety-like behavior and altered DNA methylation in the brain. This suggests microplastics may cause lasting changes to brain development through epigenetic mechanisms.
Developmental exposure to polystyrene nanoplastics induces persistent neurobehavioral changes and alters later-life susceptibility to hexabromocyclododecane in zebrafish
Researchers exposed zebrafish embryos to polystyrene nanoplastics during early development and tracked behavioral effects into adulthood. The study found that early-life nanoplastic exposure caused persistent reductions in locomotor activity and altered how adult fish responded to a common flame retardant chemical. Evidence indicates that epigenetic changes, including altered DNA methylation and gene expression patterns, may underlie these long-lasting behavioral effects.
Microplastics- and copper-induced changes in neurogenesis and DNA methyltransferases in the early life stages of zebrafish
Researchers found that exposure to microplastics and copper, alone or combined, disrupted neurogenesis and DNA methylation in zebrafish embryos, downregulating genes involved in neuronal development and suggesting epigenetic mechanisms underlying neurotoxicity.
Investigating the Epigenetic Effects of Polystyrene Nanoplastic Exposure in Bluegill (Lepomis macrochirus) Epithelial Cells Using Methylation-Sensitive AFLPs
Researchers exposed bluegill fish cells to polystyrene nanoplastics and examined whether the exposure caused changes in DNA methylation, a type of genetic modification that can alter how genes function. They found that nanoplastic exposure did cause methylation changes across the genome, but the effect was not dependent on dose or exposure time -- simply being exposed to nanoplastics was enough to trigger the changes. The findings suggest that even low-level nanoplastic exposure could have epigenetic effects on aquatic organisms.
Microplastic exposure is associated with epigenomic effects in the model organism Pimephales promelas (fathead minnow)
Researchers exposed fathead minnows to microplastics and found changes in DNA methylation -- a chemical modification that controls which genes are turned on or off -- across multiple organs including the brain, liver, and gonads. These epigenetic changes are heritable, meaning microplastic exposure could affect not just the exposed fish but also future generations, raising concerns about long-term ecological and evolutionary impacts.
Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish
Researchers exposed larval zebrafish to two sizes of polystyrene microplastics and found significant changes in gut microbiome composition and metabolic activity. The microplastics altered the abundance and diversity of gut bacteria and disrupted metabolic pathways important for development. The study suggests that early-life exposure to microplastics could have meaningful biological consequences by reshaping the gut environment of developing organisms.
Epigenetic and Gene Expression Responses in Daphnia magna to Polyethylene and Polystyrene Microplastics
Researchers exposed water fleas (Daphnia magna) to polyethylene and polystyrene microplastics and examined changes at the genetic and molecular level. They found that the microplastics altered DNA methylation patterns and disrupted the expression of genes involved in reproduction and stress response. The study provides evidence that microplastic exposure can cause changes beyond physical harm, affecting organisms at the epigenetic level.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos
Zebrafish embryos exposed to polystyrene microplastics showed brain damage, abnormal behavior, and changes in a key brain development gene called BDNF that controls nerve cell growth and survival. The microplastics triggered oxidative stress and activated cell-death pathways in developing brain tissue. These findings raise concerns that microplastic exposure during early development could interfere with brain formation and function.
Early-life microplastic exposure elicits ADHD-like behaviors by disrupting dopaminergic neurodevelopment in zebrafish
Zebrafish larvae exposed to polystyrene microplastics during early development showed ADHD-like hyperactivity and impulsivity, along with a ~30% increase in dopaminergic neurons. Transcriptomic analysis confirmed dysregulation of dopamine-associated signaling pathways, suggesting early-life microplastic exposure may impair neurodevelopment.
Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio
Researchers exposed zebrafish embryos to polystyrene microplastics during early development and observed serious physical deformities, particularly in the spine, tail, and eyes, despite no increase in mortality. The exposed larvae also showed elevated expression of genes involved in oxidative stress defense and cellular detoxification. The findings suggest that microplastics can disrupt critical developmental stages in freshwater fish even when they do not directly cause death.
Microplastics alter development, behavior, and innate immunity responses following bacterial infection during zebrafish embryo-larval development
Researchers found that polystyrene microplastics altered zebrafish larval development, behavior, and innate immune responses in a timing-dependent manner, with early embryonic exposure through the egg chorion amplifying susceptibility to subsequent bacterial infection.
Poly-lactic Acid Nanoplastics Bioccumulate in Developing Zebrafish and Induce Epigenetic Changes
PLA nanoplastics were found to bioaccumulate in zebrafish embryos and larvae during development, and exposure induced epigenetic changes including altered DNA methylation patterns, raising concern about transgenerational effects from biodegradable plastic degradation products.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
Exposure to polystyrene microplastics induced gene modulated biological responses in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics and analyzed changes in gene expression related to immune response, oxidative stress, and endocrine function. They found that microplastic exposure modulated genes involved in inflammation and detoxification pathways, indicating biological stress at the molecular level. The study provides evidence that microplastics can trigger gene-level disruptions in fish even before visible physical symptoms appear.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences
Researchers exposed developing zebrafish larvae to polystyrene nanoplastics of two sizes and found dose-dependent accumulation in tissues along with swimming hyperactivity, despite no effects on mortality or hatching. Transcriptomic analysis revealed changes in gene expression associated with neurodegeneration and motor dysfunction at both high and low concentrations. The study suggests that nanoplastic exposure during early development can alter brain function and behavior in ways that may reduce organismal fitness.
Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development
Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.
Exposure to microplastics decreases swimming competence in larval zebrafish (Danio rerio)
Researchers exposed zebrafish embryos and larvae to polystyrene microplastics and found that the particles adhered to egg surfaces before being ingested into the stomach and intestines after hatching. At higher concentrations, exposed larvae showed significantly reduced swimming distance and speed, along with upregulated genes related to inflammation and oxidative stress. The study suggests that microplastic exposure can impair swimming ability in larval fish, which could have broader ecological consequences for population fitness.
Changes in global methylation patterns of Mytilus galloprovincialis exposed to microplastics
Researchers found that exposing mussels to polystyrene microplastics caused changes in their DNA methylation patterns, an epigenetic modification that controls how genes are turned on and off. Higher microplastic concentrations led to greater loss of methylation, and similar patterns were seen in wild mussels from polluted areas. This suggests microplastics could affect organisms at the genetic regulation level, potentially influencing metabolism and cell division.
Behavioural impact of microplastics on zebrafish development
Researchers assessed the developmental effects of environmentally relevant, household-derived microplastic fragments on zebrafish, rather than the pristine polymer spheres typically used in lab studies. While exposure did not cause embryonic death or gross malformations, the study found significant sublethal effects including reduced touch-evoked escape responses in larvae, suggesting behavioral impacts from realistic microplastic exposure.