We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans
ClearNeurotoxicity induced by aged microplastics from plastic bowls: Abnormal neurotransmission in Caenorhabditis elegans
Researchers found that microplastics released from aged plastic bowls caused nerve damage in the roundworm C. elegans at environmentally realistic concentrations. The aged microplastics disrupted neurotransmitter systems including dopamine and serotonin, leading to impaired movement. This study is concerning because it shows that everyday plastic items we use for food can release microplastics that have neurotoxic effects.
Neuronal damage induced by nanopolystyrene particles in nematodeCaenorhabditis elegans
C. elegans nematodes were chronically exposed to nanopolystyrene particles and found to develop neuronal damage affecting both development and function of the nervous system after long-term exposure at environmentally relevant concentrations. The study provides early evidence that nanoplastics can cause neurological harm in an animal model, raising questions about potential neurotoxicity in other species.
Behavioral and molecular neurotoxicity of thermally degraded polystyrene in Caenorhabditis elegans
This study found that thermally degraded polystyrene, the kind created when plastic is burned or heated, was significantly more toxic to the nervous system than fresh polystyrene in laboratory worms. The heat-altered plastic caused damage to multiple types of neurons and reduced levels of key brain chemicals like dopamine and serotonin. This is concerning because burned or heated plastic waste is common in the environment, and these findings suggest it may pose greater neurological risks than previously recognized.
Polystyrene (nano)microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects inCaenorhabditis elegans
Researchers found that polystyrene micro- and nanoplastics cause neurotoxicity and oxidative damage in the model organism C. elegans, with effects varying by particle size. Smaller nanoscale particles tended to cause more severe toxic responses than larger microplastic particles. The study highlights that the size of plastic particles is an important factor in determining how harmful they are to living organisms.
Environmentally persistent free radicals on photoaged nanopolystyrene induce neurotoxicity by affecting dopamine, glutamate, serotonin and GABA in Caenorhabditis elegans
Researchers found that when polystyrene nanoplastics age under sunlight, they generate environmentally persistent free radicals on their surface that make them significantly more toxic to the nervous system. Using the model organism C. elegans, they showed that aged nanoplastics disrupted movement and reduced levels of key neurotransmitters including dopamine, serotonin, and GABA. The study suggests that weathered nanoplastics in the environment may pose greater neurological risks than freshly produced particles.
Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans
Researchers exposed Caenorhabditis elegans to nanopolystyrene and characterized changes in tyramine and glutamate neurotransmitter pathways, finding that nanoplastic exposure disrupted both signaling systems and that mutations in these pathways altered the worm's sensitivity to nanoplastic toxicity.
Exposure to nanopolystyrene and its 4 chemically modified derivatives at predicted environmental concentrations causes differently regulatory mechanisms in nematode Caenorhabditis elegans
Researchers found that nanopolystyrene and four chemically modified derivatives caused distinct toxicity patterns in C. elegans nematodes at environmentally predicted concentrations, with surface chemistry significantly influencing the regulatory mechanisms affected.
Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans
Researchers found that UV-aged microplastics caused more severe neurotoxic effects than pristine microplastics when worms were chronically exposed to low concentrations. The aged particles disrupted dopamine, glutamate, and serotonin signaling pathways and caused visible neurodegeneration in the test organisms. The study suggests that microplastics become more harmful as they weather in the environment, which is an important consideration for assessing real-world exposure risks.
Biochemical and physiological effects of multigenerational exposure to spheric polystyrene microplastics in Caenorhabditis elegans
Researchers found that multigenerational exposure of C. elegans to polystyrene microplastics at low concentrations triggered oxidative stress, increased detoxification enzyme activity, and caused accumulating physiological effects across five consecutive generations.
Comparison of transgenerational reproductive toxicity induced by pristine and amino modified nanoplastics in Caenorhabditis elegans
Researchers compared transgenerational toxicity of pristine and amino-modified polystyrene nanoplastics in C. elegans, finding that the amino-modified (NPS-NH₂) variant caused reproductive toxicity and gonad damage at 10-fold lower concentrations than unmodified NPS and had more severe cross-generational effects.
Different Toxic Effects of Polystyrene Microplastics and Nanoplastics on Caenorhabditis elegans
Researchers compared the toxicity of 2-μm polystyrene microplastics and 0.1-μm nanoplastics in C. elegans, finding both impaired growth, locomotion, reproduction, and lifespan at 1 mg/L and above, with microplastics causing greater locomotion and reproductive toxicity and nanoplastics inducing stronger oxidative stress.
Polystyrene microplastics (PS-MPs) toxicity induced oxidative stress and intestinal injury in nematode Caenorhabditis elegans
Researchers exposed the nematode C. elegans to various concentrations of polystyrene microplastics and measured physiological, biochemical, and molecular responses. The study found that microplastics accumulated in the intestine and caused oxidative stress, intestinal injury, and adverse physiological effects at concentrations as low as 1 microgram per liter, suggesting that even low-level microplastic exposure can damage gut tissues.
Neurodevelopmental Toxicity of Polystyrene Nanoplastics inCaenorhabditis elegansand the Regulating Effect of Presenilin
C. elegans exposed to 25, 50, and 100 nm polystyrene nanoplastics showed size-dependent neurodevelopmental toxicity — including reactive oxygen species generation, mitochondrial damage, and inhibited dopamine production — with smaller particles (25 nm) paradoxically showing weaker effects than the 50 nm size.
Photoaged microplastics induce neurotoxicity associated with damage to serotonergic, glutamatergic, dopaminergic, and GABAergic neuronal systems in Caenorhabditis elegans
Researchers found that sunlight-aged microplastics caused more severe brain and nerve damage than fresh microplastics in lab worms, disrupting four major neurotransmitter systems: serotonin, glutamate, dopamine, and GABA. Even at very low, environmentally realistic concentrations, the aged particles impaired movement and altered gene expression related to nerve signaling. Since most microplastics in the real world have been weathered by sunlight, this study suggests that the neurotoxic risks of environmental microplastic exposure may be greater than studies using pristine particles indicate.
A Multisystemic Approach Revealed Aminated Polystyrene Nanoparticles-Induced Neurotoxicity.
Aminated polystyrene nanoparticles caused neurotoxicity in multiple model systems, including effects on neuronal cell viability, oxidative stress markers, and behavioral changes in exposed organisms, demonstrating that surface charge of nanoplastics influences their capacity to damage nervous tissue.
Exploring the mechanisms of neurotoxic effects from combined exposure to polystyrene and microcystin-LR in Caenorhabditis elegans
Researchers studied the combined neurotoxic effects of polystyrene microplastics and the cyanotoxin microcystin-LR in an animal model, finding synergistic damage to brain tissue through oxidative stress and neuroinflammation pathways beyond what either contaminant caused alone.
Environmentally relevant concentrations of polystyrene nanoplastics induce Parkinson’s-like neurotoxicity in C. elegans via oxidative stress
Researchers exposed roundworms to environmentally realistic concentrations of polystyrene nanoplastics and observed movement problems and brain changes resembling Parkinson's disease. The nanoplastics selectively damaged dopamine-producing neurons and increased toxic protein clumping through oxidative stress, and when an antioxidant treatment was applied, it partially reversed the harmful effects.
The toxic differentiation of micro- and nanoplastics verified by gene-edited fluorescent Caenorhabditis elegans
Researchers used gene-edited fluorescent C. elegans to demonstrate that nanoplastic toxicity is size- and charge-dependent, with 100 nm positively charged polystyrene particles causing the greatest harm through intestinal accumulation and oxidative stress.
Transgenerational neurotoxicity of polystyrene microplastics induced by oxidative stress in Caenorhabditis elegans
Researchers exposed the roundworm C. elegans to polystyrene microplastics and tracked the effects across five generations. They found that microplastic exposure caused nerve damage and oxidative stress that persisted in offspring even when those generations were not directly exposed, suggesting microplastics can have lasting effects passed down through generations.
UV-aged microplastics induces neurotoxicity by affecting the neurotransmission in larval zebrafish
Researchers compared the neurotoxic effects of fresh versus UV-aged polystyrene microplastics on zebrafish larvae. They found that aged microplastics caused more severe behavioral changes and significantly altered levels of key brain chemicals including dopamine, serotonin, and acetylcholine. The study demonstrates that environmental weathering makes microplastics more neurotoxic, which is an important consideration for assessing the real-world risks of plastic pollution in aquatic ecosystems.
Sulfate-modified nanosized polystyrene impairs memory by inhibiting ionotropic glutamate receptors and the cAMP-response element binding protein (CREB) pathway in Caenorhabditis elegans
Researchers found that sulfate-modified polystyrene nanoplastics impair both short- and long-term associative memory in C. elegans by downregulating ionotropic glutamate receptors and the CREB signaling pathway — conserved molecular mechanisms that also underlie learning and memory in mammals — raising concerns about nanoplastic effects on cognition.
Photoaged Nanopolystyrene Affects Neurotransmission to Induce Transgenerational Neurotoxicity in Caenorhabditis elegans
When tiny roundworms were exposed to sunlight-aged nanoplastics, their offspring showed movement problems and damaged nerve cells for up to two generations, even without further exposure. The aged nanoplastics were more harmful than fresh ones and worked by disrupting key brain chemicals like dopamine and serotonin, suggesting that weathered plastic particles in the environment may pose greater risks to nervous system health across generations.
The role of Sod-2 in different types of neuronal damage and behavioral changes induced by polystyrene nanoplastics in Caenorhabditis elegans
Researchers used the roundworm C. elegans to study how polystyrene nanoplastics damage the nervous system at concentrations found in agricultural soils. They found that the nanoplastics caused nerve damage in a specific order, first affecting dopamine neurons, then acetylcholine neurons, and finally GABA neurons, through a process involving oxidative stress and reduced antioxidant protein levels. The study identifies a specific cellular pathway through which nanoplastics cause neurotoxic effects, and shows that a mitochondrial antioxidant could help alleviate the damage.
The plastic brain: neurotoxicity of micro- and nanoplastics
This review examines the emerging evidence that micro- and nanoplastics can reach the brain in both aquatic animals and mammals, potentially causing neurotoxic effects. Researchers found that exposure to these particles induces oxidative stress, inhibits key enzymes involved in nerve signaling, and alters neurotransmitter levels, which may contribute to behavioral changes. The study highlights that systematic research comparing different particle types, sizes, and exposure conditions is urgently needed to understand the neurological risks.