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61,005 resultsShowing papers similar to State-of-the-art mass spectrometry imaging applications in biomedical research
ClearMini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024
This mini review highlights recent advances in MALDI mass spectrometry imaging, a technology that can visualize hundreds of molecules in tissue samples in a single experiment. While focused on clinical diagnostics and pharmacology applications, this imaging technology is increasingly relevant for detecting and mapping where microplastics and nanoplastics accumulate in human tissues.
In situ imaging of microplastics in living organisms based on mass spectrometry technology
Researchers reviewed mass spectrometry-based imaging techniques for detecting microplastics inside living organisms, comparing different ion source methods for their ability to visualize plastic particles in biological tissue. They found that these techniques can provide both spatial distribution maps and chemical composition analysis of microplastics at high resolution. The study suggests that mass spectrometry imaging could become a powerful tool for understanding how microplastics accumulate and distribute within living systems.
Environmental Applications of Mass Spectrometry for Emerging Contaminants
This review covers how mass spectrometry, a powerful analytical technique, is being used to detect and measure emerging contaminants including microplastics and nanoplastics in the environment. Advances in this technology are enabling researchers to identify smaller plastic particles and trace the chemical additives they carry, which is critical for understanding human exposure risks.
Raman Imaging Spectroscopy: History, Fundamentals and Current Scenario of the Technique
This review covers the history and principles of Raman imaging spectroscopy, a technique increasingly used to identify and map the chemical composition of microplastics in environmental samples. The review provides technical context for one of the most important tools in microplastic analysis.
Chemical Fingerprinting: Advances in Analytical Techniques for Environmental Monitoring
This review examines advances in chemical fingerprinting techniques, including mass spectrometry and NMR spectroscopy, for identifying and tracking pollutants in the environment. Researchers discuss how these analytical methods can be applied to monitor complex chemical mixtures including microplastics across environmental media. The study suggests that improved fingerprinting approaches could enhance our ability to trace pollution sources and assess ecological risks.
Molecular Imaging, Radiochemistry, and Environmental Pollutants
This review examines how molecular imaging and radiotracer chemistry techniques can be used to track how environmental pollutants — including plastics-related chemicals — move through living bodies at very low, realistic concentrations. These methods can reveal where pollutants accumulate in tissues and how quickly they are processed or retained, providing data that traditional toxicology studies miss. The authors highlight the potential of these tools to better characterize the health risks posed by emerging contaminants like microplastic-associated chemicals.
Synchrotron-based Spectromicroscopy for Microplastic Detection and Characterization
Researchers reviewed how synchrotron-based imaging techniques — which use powerful X-ray beams to see extremely fine details — can detect and chemically identify micro- and nanoplastics that conventional methods miss, including plastics absorbed into biological tissues. These high-resolution tools are still in early stages but show strong potential for mapping microplastic contamination at the nanoscale.
Mass spectrometry-based multimodal approaches for the identification and quantification analysis of microplastics in food matrix
This review examines mass spectrometry techniques for identifying and measuring microplastics in food, covering methods that analyze both the chemical composition and quantity of plastic particles. The study suggests these advanced analytical approaches could help bridge the gap between environmental monitoring and understanding actual human exposure levels. Better measurement tools are needed to assess how much microplastic people are consuming through their diet.
Exposomics as a discovery engine for emerging contaminants and hidden biological risks
This review examined how exposomics—the science of comprehensively characterizing all chemical exposures an individual encounters—has matured into a practical discovery tool for identifying emerging contaminants and hidden health risks. The authors found that high-resolution mass spectrometry combined with multi-omics and wearable sensors can uncover chemical exposures missed by conventional targeted monitoring.
Advancing microplastic and associated pollutants detection: A comprehensive review on high-sensitivity analysis using mass spectrometry techniques
This review evaluates mass spectrometry techniques for detecting microplastics and the toxic pollutants they carry, including trace metals and volatile organic compounds. Advanced approaches like gold nanoparticle labeling and laser-based mapping are enabling researchers to better understand how microplastics act as transport vehicles for harmful substances in both environmental and biological samples.
Integrative Forensic Methods in Food Contaminant Detection and Identification
This review examines integrative forensic methods for detecting and identifying contaminants in food, synthesizing advanced analytical techniques including spectroscopy, chromatography, and imaging approaches that improve the precision of food safety monitoring for emerging pollutants.
Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles
This review evaluates advanced mass spectrometry techniques for studying how metallic nanoparticles behave in biological systems, including how they enter cells, where they accumulate, and how they transform inside the body. While focused on metal nanoparticles rather than microplastics, many of the same analytical methods are being applied to track nanoplastics in tissues. Better tools for detecting and measuring tiny particles in the body are essential for understanding the real health impacts of nanoplastic exposure.
Exposomics as a discovery engine: a systematic scoping review of emerging environmental contaminants and novel biological effects
This scoping review mapped how exposomics tools—including high-resolution mass spectrometry, multi-omics integration, and wearable sensors—have been applied over the past decade to discover novel environmental contaminant exposures and their health effects. It found emerging contaminants like microplastics and PFAS increasingly captured by non-targeted approaches.
MALDI mass spectrometry imaging workflow for the aquatic model organisms Danio rerio and Daphnia magna
Researchers developed a detailed imaging technique using mass spectrometry to map the location of lipids (fats) throughout the bodies of zebrafish and water fleas, two key species used in pollution studies, providing a new tool to detect how environmental contaminants disrupt fat metabolism at the tissue level.
In Situ Identification and Spatial Mapping of Microplastic Standards in Paramecia by Secondary-Ion Mass Spectrometry Imaging
Researchers used secondary-ion mass spectrometry imaging to identify and spatially map microplastic particles inside paramecia, demonstrating that the technique can localize specific polymer types within unicellular organisms at subcellular resolution, offering a new tool for studying how microplastics interact with cell structures.
Facets of ICP-MS and their potential in the medical sciences—Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays
Researchers review how inductively coupled plasma mass spectrometry (ICP-MS), a technique that measures trace elements in biological samples, has expanded into medical fields like nanomedicine, cancer diagnostics, and disease biomarker detection. This powerful analytical tool is enabling personalized medicine by allowing scientists to simultaneously analyze both elements and biomolecules at very low concentrations.
Applications of Tandem Mass Spectrometry (MS/MS) in Protein Analysis for Biomedical Research
This review covers how tandem mass spectrometry is used to analyze proteins and peptides in biomedical research, including identifying protein sequences and modifications. The technology enables researchers to detect disease biomarkers and understand protein changes relevant to diagnostics and therapy. While not directly related to microplastics, these analytical methods are part of the broader toolkit used in environmental and health research.
Raman Spectroscopic Imaging of Human Bladder Resectates towards Intraoperative Cancer Assessment
Researchers used Raman spectroscopy imaging to distinguish between healthy and cancerous human bladder tissue without the need for chemical stains or labels. The technique successfully identified cancer regions in tissue samples from ten patients, using advanced data analysis to map molecular differences. While not directly related to microplastics, this spectroscopy method is also used in microplastic research and demonstrates the power of label-free chemical imaging in medical applications.
Is LA-ICP-MS the next frontier in monitoring and imaging microplastics in biological tissues?
This paper evaluated whether laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) could become a leading technique for detecting and imaging microplastics within biological tissues. If validated, this approach could allow researchers to precisely map where plastic particles accumulate in organs, greatly improving understanding of how microplastics affect living organisms including humans.
Is LA-ICP-MS the next frontier in monitoring and imaging microplastics in biological tissues?
This paper evaluated whether laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) could become a leading technique for detecting and imaging microplastics within biological tissues. If validated, this approach could allow researchers to precisely map where plastic particles accumulate in organs, greatly improving understanding of how microplastics affect living organisms including humans.
Hyperspectral imaging: An early systematic review of emerging applications for rapid microplastic analysis
This systematic review examines the emerging use of hyperspectral imaging technology for detecting and analyzing microplastics in environmental samples. Better detection methods matter for human health because accurately measuring microplastic contamination in water, food, and air is essential for understanding our true level of exposure and developing effective strategies to reduce it.
Static headspace-gas chromatography with mass spectrometry for the assessment of the bioaccumulation of volatile organic compounds associated with microplastics in animal tissues
Researchers developed an analytical method using headspace gas chromatography with mass spectrometry to detect volatile organic compounds that migrate from microplastics into animal tissues. The technique demonstrated high sensitivity and precision while requiring minimal sample handling. The methodology provides a valuable tool for understanding how chemical compounds associated with microplastics accumulate in living organisms.
Principles and Applications of Vibrational Spectroscopic Imaging in Plant Science: A Review
This review covers the principles and applications of vibrational spectroscopic imaging techniques including infrared and Raman spectroscopy in plant science, highlighting their capacity to provide spatially distributed chemical information from organ to sub-cellular scales without destructive sampling. The authors survey applications across plant biochemistry, structural analysis, and secondary metabolite localization, demonstrating the utility of these methods for both basic and applied botanical research.
Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment
This review evaluates mass spectrometry techniques for detecting microplastics in the environment, covering GC-MS, LC-MS, MALDI-MS, and pyrolysis-based methods while comparing their capabilities for polymer identification, quantification, and size characterization.