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61,005 resultsShowing papers similar to Microplastic Effects on Thrombin-Fibrinogen Clotting Dynamics Measured via Turbidity
ClearMicroplastic Effects on Thrombin–Fibrinogen Clotting Dynamics Measured via Turbidity and Thromboelastography
Researchers found that microplastics directly altered fibrin clot formation dynamics in a human thrombin-fibrinogen model, with effects varying by plastic type, size, and concentration, suggesting potential impacts on blood clotting and cardiovascular health.
Exploring microplastic impact on whole blood clotting dynamics utilizing thromboelastography
Researchers used a blood clotting analysis technique to study how polystyrene microplastics of different sizes and surface types affect human blood clotting. They found that negatively charged particles consistently activated the clotting process, increasing both the speed and strength of clot formation in a size-dependent manner. The findings highlight that microplastic surface chemistry and particle size play important roles in how these particles might interact with blood.
Interaction of polystyrene nanoplastics with human fibrinogen
Researchers found that polystyrene nanoplastics with different surface modifications disrupted the structure of human fibrinogen, a key blood clotting protein, in a dose-dependent manner. The study suggests that nanoplastics entering the bloodstream could interfere with protein function, raising concerns about the potential biological consequences of nanoplastic exposure in humans.
PB1065 Microvesicles Display Opposite Coagulolytic Balances According to Their Cellular Origin and Activation Status
Polystyrene microplastics activated human vascular endothelial cells, upregulating inflammation markers ICAM-1 and VCAM-1, and promoted larger and denser blood clot formation when added to whole blood perfused over collagen at concentrations found in human plasma. These results raise concern that microplastics circulating in human blood could increase the risk of thrombosis and cardiovascular events.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Weathered microplastics in human blood: unraveling the effect of structural changes at the particle surface on coagulation and platelet activation
Researchers exposed human whole blood to microplastics that had been artificially aged to simulate real environmental weathering, finding that weathered plastics like polystyrene, PVC, and PET triggered significantly stronger blood clotting and platelet activation than fresh plastic particles. The findings suggest that the longer plastic sits in the environment and degrades, the more dangerous it may become to human cardiovascular health.
Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins
Researchers found that polystyrene nanoplastics can enter the bloodstream and increase the risk of blood clots by adsorbing key clotting proteins, particularly coagulation factor XII and plasminogen activator inhibitor-1. This protein-adsorption mechanism was confirmed through multiple analytical approaches. The discovery of this thrombosis-promoting pathway is concerning because it suggests that nanoplastic exposure could increase cardiovascular risks like stroke and heart attack.
Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats
Researchers investigated whether polystyrene nanoplastics promote blood coagulation activity in human red blood cells. The study found that amine-modified 100 nm nanoplastics were taken up by red blood cells, caused morphological changes, induced phosphatidylserine externalization, and generated microvesicles, suggesting that certain nanoplastics may promote procoagulant activity and potentially contribute to thrombus formation.
Microplastic particles in human blood and their association with coagulation markers
In a study of 36 healthy adults, microplastics were detected in the blood of 89% of participants, with polypropylene and polyethylene being the most common types found. Higher microplastic levels were associated with changes in blood clotting markers, suggesting that plastic particles in our bloodstream may affect how our blood coagulates, though larger studies are needed to confirm this link.
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity
Researchers developed a microfluidic-based thrombosis model to study how microplastics interact with the vascular system. Using both a mouse model and an on-chip system, the study found that microplastic exposure led to accumulation in the blood and decreased binding of fibrin to platelets, suggesting a potential risk of thrombus instability in blood flow.
Circulating Microplastics as Acute Triggers of Platelet Activation and Coagulation: Implications for Cardiovascular Risk
Researchers exposed human platelets to nanoplastics and found direct activation of platelet aggregation and coagulation pathways at environmentally relevant concentrations. The results suggest that circulating microplastics and nanoplastics could act as acute triggers of thrombosis, with implications for cardiovascular disease risk.
Aggregation kinetics of different surface-modified polystyrene nanoparticles in monovalent and divalent electrolytes
Researchers investigated how surface chemistry and morphology affect the clumping behavior (aggregation kinetics) of polystyrene nanoplastics in water, finding that surface charge and functional groups strongly govern stability, while dissolved organic matter can either inhibit or promote aggregation depending on concentration and whether mono- or divalent ions are present.
Impact of coagulation characteristics on the aggregation of microplastics in upper-ocean turbulence
This study investigated how coagulation conditions affect microplastic aggregation in water treatment, finding that coagulant type and dose significantly influence floc formation with plastic particles and ultimately removal efficiency.
Influence of polystyrene microplastics on the structural stability of activated sludge microbial flocs in sequencing batch reactors
Researchers exposed sequencing batch reactors to polystyrene microplastics at 0, 10, and 100 mg/L and measured effects on activated sludge floc structure. Microplastic exposure caused a 7.8-13.3% reduction in floc density and a significant rise in effluent turbidity, impairing sludge settling and potentially reducing wastewater treatment efficiency.
Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice
Researchers exposed mice to polystyrene nanoplastics with different surface modifications and found that the particles caused structural damage to vascular endothelial cells and triggered inflammatory responses. The nanoplastics also disrupted blood coagulation function in the mice. The study suggests that nanoplastic exposure may pose risks to cardiovascular health due to the particles' ability to travel through the bloodstream and damage blood vessel linings.
Comparative effects of crystalline, poorly crystalline and freshly formed iron oxides on the colloidal properties of polystyrene microplastics
Researchers found that freshly formed iron oxides caused the greatest aggregation of polystyrene microplastics in water, with effects decreasing in the order: freshly formed iron oxide > ferrihydrite > goethite > haematite. The findings suggest that iron oxide copresence can delay microplastic transport or alter their environmental fate depending on pH and crystallinity of the mineral.
Effects of organic matter on interaction forces between polystyrene microplastics: An experimental study
Researchers examined how organic matter in seawater affects the aggregation and adhesion forces between polystyrene microplastics, finding that organic coatings alter surface interaction forces in ways that influence whether microplastics clump together and sink or remain dispersed in the water column.
Effects of size and surface charge on the sedimentation of nanoplastics in freshwater
Researchers investigated how size and surface charge of polystyrene nanoplastics affect their sedimentation behavior in freshwater, finding that both properties significantly influence aggregation dynamics and settling rates, with implications for predicting nanoplastic fate in aquatic environments.
Enhanced Removal of Polystyrene Microplastics from Water Through Coagulation Using Polyaluminum Ferric Chloride with Coagulant Aids
Researchers tested enhanced coagulation using modified coagulants to remove polystyrene microplastics from water, finding that surface-modified coagulants achieved significantly higher removal efficiencies than conventional alum. Removal reached over 90% under optimized conditions, demonstrating a practical upgrade pathway for conventional water treatment plants to reduce microplastic discharge.
Phenolic-modified cationic polymers as coagulants for microplastic removal
Researchers developed phenolic-modified cationic polymer coagulants inspired by natural metal-phenolic coordination chemistry, achieving over 90% removal of polystyrene microplastics from water. The surface modification approach simplified the two-step coagulation process and expanded the range of effective coagulant materials.
Aggregation kinetics of microplastics in aquatic environment: Complex roles of electrolytes, pH, and natural organic matter
Researchers found that the aggregation behavior of polystyrene microplastics in water was strongly influenced by pH, ionic strength, and the presence of natural organic matter, with divalent cations like calcium and magnesium promoting aggregation. Understanding aggregation kinetics is critical for predicting how microplastics partition between suspended and settled states in natural water bodies.
Effect of surface functional groups of polystyrene micro/nano plastics on the release of NOM from flocs during the aging process
Researchers studied how polystyrene micro- and nanoparticles with different surface functional groups affect the release of natural organic matter from coagulation flocs during aging. They found that smaller nanoparticles had a greater impact on natural organic matter release than larger microplastics. The study highlights a hidden risk in water treatment, where microplastics in the coagulation process could compromise the effectiveness of removing organic contaminants from drinking water.
Effect of Microplastics on the Coagulation Mechanism of Polyaluminum–Titanium Chloride Composite Coagulant for Organic Matter Removal Revealed by Optical Spectroscopy
This study investigated how microplastics interfere with a water treatment coagulant (PATC) designed to remove dissolved organic matter from drinking water. High concentrations of aged polystyrene microplastics competed with organic matter for active binding sites on the coagulant, reducing its effectiveness at removing certain compounds while also slowing the breakdown of its most reactive component. The results show microplastics in source water can compromise the efficiency of conventional water purification processes.
The crucial role of a protein corona in determining the aggregation kinetics and colloidal stability of polystyrene nanoplastics
Time-resolved dynamic light scattering was used to study how protein coronas — protein layers that form on nanoplastics in biological or environmental fluids — control the aggregation kinetics and colloidal stability of polystyrene nanoplastics. Protein identity and concentration profoundly shifted nanoplastic behavior, with implications for how these particles move and persist in natural water systems.